摘要
目的探讨血清胱抑素C(CysC)、β2微球蛋白(β2-MG)与不同病程类风湿关节炎患者肾功能损害的关系,为临床早期诊断肾功能受损提供理论基础。方法选取我院2016年12月至2018年10月收治的90例类风湿关节炎患者为研究对象,根据不同病程将其分为A、B、C三组,每组30例。比较三组患者的CysC、β2-MG、BUN和Cr异常检出率及水平,并比较不同年龄段患者的CysC、β2-MG水平。结果三组患者的CysC和β2-MG异常检出率均随着病程的延长呈现递增趋势,且C组患者的CysC、β2-MG异常检出率均显著高于A、B组,差异具有统计学意义(P<0.05)。A组和B组患者的BUN和Cr异常检出率均为0.00%,BUN和Cr异常检出率在C组发生变化。三组患者CysC、β2-MG、BUN和Cr水平随着病程的延长均呈递增趋势,且三组CysC、β2-MG、BUN和Cr水平比较,差异具有统计学意义(P<0.05)。42~81岁患者的CysC与β2-MG水平均显著高于21~41岁患者,差异具有统计学意义(P<0.05)。结论CysC和β2-MG的检测有助于对类风湿关节炎患者肾小管和肾小球功能受损进行早期诊断,且这两项检测指标与类风湿关节炎患者的病情发展密切相关,有助于判定患者的预后,值得临床推广与应用。
Objective To analyze the relationship between serum cystatin C(Cys C),β2 microglobulin(β2-MG)and renal dysfunction in patients with rheumatoid arthritis of different course,so as to provide theoretical basis for early clinical diagnosis of renal function impairment.Methods Ninety patients with rheumatoid arthritis admitted and treated in our hospital from December 2016 to October 2018 were selected as the research objects.According to the different course of the disease,the patients were divided into groups A,B and C,with 30 cases in each group.The abnormal detection rates and levels of Cys C,β2-MG,BUN and Cr were compared between the three groups,and the levels of Cys C andβ2-MG in different age groups were compared.Results The abnormal detection rates of Cys C andβ2-MG of patients in the three groups showed an increasing trend with the prolongation of the disease course,the abnormal detection rates of Cys C andβ2-MG of patients in the group C were significantly higher than those in the group A and B,and the differences were statistically significant(P<0.05).The abnormal detection rates of BUN and Cr in group A and B were both 0.00%,and the abnormal detection rates of BUN and Cr were changed in group C.The levels of Cys C,β2-MG,BUN and Cr of patients in the three groups showed an increasing trend with the prolongation of the disease course,the levels of Cys C,β2-MG,BUN and Cr in the three groups were statistically significant(P<0.05).The levels of Cys C andβ2-MG in patients of 42-81 years old were significantly higher than those in patients of 21-41 years old(P<0.05).Conclusion The detections of Cys C andβ2-MG contributes to the early diagnosis of renal tubular and glomerular dysfunction in rheumatoid arthritis patients,which are closely related to the development of rheumatoid arthritis patients and helpful to determine the prognosis of patients,and are worthy of clinical promotion and application.
作者
袁维
高蔼萍
YUAN Wei;GAO Ai-ping(Shangluo Central Hospital,Shangluo 726000,China)
出处
《临床医学研究与实践》
2019年第23期94-96,共3页
Clinical Research and Practice
