摘要
目的分析定量测定女童尿促性腺激素判断性发育程度的临床价值,为女童性发育异常筛查提供简便快速的方法。方法选取2015年12月至2017年12月德阳市中西医结合医院就诊的184例女童作为研究对象。所有女童表现出乳房发育症状,均经血清促黄体生成素、血清卵泡生成素检查或GnRH激发试验检查,并行尿卵泡生成素和尿促黄体生成素检查。按照《中枢性(真性)性早熟诊治指南》2007版本中对性早熟的诊断标准诊断受试女童是否性早熟。按照是否性早熟将女童分为性早熟组(69例)和非性早熟组(115例)。比较两组女童的尿卵泡生成素和尿促黄体生成素差异。结合性早熟指南标准诊断结果,对所有女童进行尿卵泡生成素和尿促黄体生成素做ROC曲线,确定尿卵泡生成素和尿促黄体生成素的左侧拐点为诊断临界限值,分别计算尿卵泡生成素、尿促黄体生成素单独和二者结合诊断女童性早熟的特异度和敏感度。结果性早熟组女童尿卵泡生成素和尿促黄体生成素均明显高于非性早熟组,差异具有统计学意义(P<0.05)。女童尿卵泡生成素和尿促黄体生成素诊断性早熟的临界限值分别为:1.60(U/mmol)、5.67(U/mmol)。尿卵泡生成素、尿促黄体生成素及尿卵泡生成素+尿促黄体生成素诊断性早熟的敏感度分别为:76.81%、88.41%、89.85%,特异度分别为:90.43%、95.65%、96.52%。尿卵泡生成素+尿促黄体生成素对女童性早熟的诊断价值高于单一指标诊断。结论尿卵泡生成素和尿促黄体生成素可简便快捷地判断女童是否出现性早熟,为女童健康体检筛查性早熟提供参考,具有较高的临床价值。
Objective To analyze the clinical value of quantitative determination of gonadotropin in urine in the prediction of female sexual development, in order to provide a simple and rapid method for the screening of abnormal sexual development. Methods 184 girls in our hospital from February 2015 to February 2017 were selected. All the girls showed symptoms of breast development, and received examinzation of serum luteinizing hormone(LH), serum follicle-stimulating hormone(FSH) examination or GnRH stimulation test, urinary FSH and urinary luteinizing hormone test. According to the 2007 version of Guidelines for the Diagnosis and Treatment of Central Precocious Puberty, the girls were divided into precocious puberty group(69 cases) and non precocious puberty group(n=115). The differences in urinary FSH and LH between the two groups were compared. With the guide of criteria for the diagnosis of precocious results,ROC curve of urinary FSH and urinary LH was made and the inflection point onthe left side was named as the threshold value, to calculate the sensitivity and specificity of urinary FSH, urinary LH alone and the combination of the two in the diagnosis of precocious puberty. Results The levels of urinary FSH and urinary LH in girls with precocious puberty were significantly higher than those in non precocious group, with statistically significant differences(P<0.05). The threshold value of urinary FSH and urinary LH in the diagnosis of precocious puberty was 1.60(U/mmol) and 5.67(U/mmol) respectively. The sensitivity of urinary FSH, uninary LH and the two together was 76.81%, 88.41% and 89.85% respectively, and the specificity was 90.43%, 95.65% and 96.52% accordingly. The diagnostic value of urinary FSH and and urinary LH together in female precocious puberty is higher than that of each alone. Conclusions Urinary FSH and urinary LH can be used topredict female sexual development, which provides a reference for the screening of precocious puberty.
作者
杨期辉
刘利洪
蒋炳林
陈金秀
YANG Qihui;LIU Lihong;JIANG Binglin;CHEN Jinxiu(Department of Clinical Laboratory ,Deyang Integrated Traditional Chinese and Western Medicine Hospital, Deyang 618000 ,Sichuan ,China;Department of Obstetrics and Gynecology ,Deyang Integrated Traditional Chinese and Western Medicine Hospital ,Deyang 618000 ,Sichuan,China)
出处
《中国性科学》
2019年第7期123-126,共4页
Chinese Journal of Human Sexuality
关键词
尿促性腺激素
尿卵泡生成素
尿促黄体生成素
女童性发育
GnRH激发试验
筛查方法
Urinary gonadotropin
Urinary follicle-stimulating hormone(FSH)
Urinary luteinizing hormone(LH)
Sexual development
GnRH provocation test
Screening method
