摘要
目的探究中高频全额型突发性耳聋患者中应用脑苷肌肽的价值,并对其机制进行分析。方法选取广州市红十字会医院2016年9月—2018年9月突发性耳聋患者90例,随机分为对照组、观察组。对照组采用地塞米松联合银杏制剂来治疗突发性耳聋;观察组患者采用地塞米松联合银杏叶制、剂脑苷肌肽来治疗突发性耳聋,对比两组患者治疗前后的临床总有效率、神经元损伤相关血清蛋白及不良反应。结果观察组治疗后总有效率高于对照组,差异有统计学意义(P<0.05);但观察组患者神经元损伤相关血清蛋白指标较对照组明显降低(P<0.05)。组间药物不良反应发生率相比,差异无统计学意义(P>0.05)。结论中高频、全频型突发性耳聋患者予脑苷肌肽治疗见良好效用,安全价值高。
Objective To investigate the value of cerebroside carnosine in patients with mid-high frequency and full-frequency sudden deafness, and to analyze its mechanism.Methods 90 patients with sudden deafness from September, 2016 to September, 2018 in the hospital were randomly divided into control group and observation group.The control group were treated with dexamethasone combined with ginkgo preparation for sudden deafness.The observation group were treated with dexamethasone combined with ginkgo biloba and cerebroside carnosine.The total effective rate, neuronal damage-related serum proteins and adverse reactionsbefore and after treatment was compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05).However, the serum protein index of neuron injury in the observation group was significantly lower than that of the control group (P<0.05).There was no significant difference in the incidence of adverse drug reactions between the groups (P>0.05).Conclusion The patients with mid-high frequency and fullfrequency sudden deafness have good efficacy and high safety value.
作者
于超生
邓海燕
李军政
YU Chao-sheng;DENG Hai-yan;LI Jun-zheng(Department of Otorhinolaryngology Head and Neck Surgery,Guangzhou Red Cross Hospital,Guangzhou 510200,China)
出处
《黑龙江医学》
2019年第8期891-893,共3页
Heilongjiang Medical Journal
基金
广州市红十字会医院项目（2017-22）
关键词
脑苷肌肽
中高频、全频型突发性耳聋
地塞米松
临床机制
Cerebroside carnosine
Mid-high frequency,full-frequency sudden deafness
Dexamethasone
Clinicalmechanism
