摘要
1例16岁男性患者因诊断为症状性癫痫(2017年7月)口服丙戊酸钠缓释片0.5g,2次/d;因出现发愣症状,于2018年7月18日加用拉莫三嗪片,经过2个月后加量至100mg2次/d。约第155天,患者双侧足踝、面部出现针尖大小红色斑点。停用拉莫三嗪,继续服用丙戊酸钠缓释片,1周后面部大面积出现丘疹、红斑及渗出,伴有肿胀,躯干及四肢近端出现大量红色斑疹,诊断为药源性皮疹入院,给予静脉注射人免疫球蛋白和糖皮质激素等对症治疗后,皮疹消退好转出院。
A 16-year-old male patient was given oral sodium valproate sustained release tablets 0. 5 g, twice a day,due to the diagnosis of symptomatic epilepsy in July 2017. Lamotrigine was added due to numbness on July 18, 2018. After 2 months, the dosage was increased to 100 mg, twice a day. The red spots of tip size on both sides of foot and ankle and face appeared after about 155 d. Then he stopped using lamotrigine, and continued to take sodium valproate sustained release tablets. One week later, the papules, erythema and exudation appeared in large areas of the face, accompanied by swelling and numerous red maculae on the proximal parts of trunk and limbs. Therefore, the patient was diagnosed with drug-induced skin rashes and was admitted to hospital. After symptomatic treatment with intravenous gamma globulin and glucocorticoid, the rash subsided and was improved and the patient was discharged.
作者
黄笑芳
龚丽娴
邓敏佳
宋继丽
杨晨
HUANG Xiao-fang;GONG Li-xian;DENG Min-jia;SONG Ji-li;YANG Chen(Department of Pharmacy,People's Liberation Army Southern Theater General Hospital,Guangzhou 510010,China)
出处
《实用药物与临床》
CAS
2019年第8期894-896,共3页
Practical Pharmacy and Clinical Remedies
基金
“健康夕阳红,合理用药伴君行”老年人合理用药科普知识专题宣教活动(20170901006)
关键词
拉莫三嗪
不良反应
迟发性
重症药疹
药物超敏综合征
Lamotrigine
Adverse reactions
Delayed-type
Severe drug eruption
Drug hypersensitivity syndrome
