摘要
目的探讨临床采用亚甲蓝混合激素局部封闭治疗肛门瘙痒的可行性。方法 100例肛门瘙痒患者,随机分为对照组和观察组,每组50例。对照组患者采用亚甲蓝混合曲安奈德局部封闭治疗,观察组患者采用亚甲蓝混合复方倍他米松注射液局部封闭治疗。比较两组患者疗效、瘙痒症状消失时间、皮损完全消退时间、复发情况及治疗前后症状积分、简明健康状况调查量表(SF-36)评分。结果观察组患者总有效率为100.00%,高于对照组的76.00%,差异具有统计学意义(P<0.05)。治疗后,两组患者症状积分、SF-36评分均较本组治疗前改善,且观察组改善幅度更大,差异具有统计学意义(P<0.05)。观察组患者瘙痒症状消失时间、皮损完全消退时间分别为(17.11±1.41)、(24.13±0.24)d,均短于对照组的(23.50±2.25)、(29.23±1.51)d,差异具有统计学意义(P<0.05)。两组患者复发率比较差异无统计学意义(P>0.05)。结论亚甲蓝混合复方倍他米松注射液局部封闭治疗肛门瘙痒效果显著,值得推广。
Objective To discuss the feasibility of partial closure with methylene blue mixed hormone for the treatment of anal itch. Methods A total of 100 anal itch patients were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with partial closure with methylene blue mixed hormone, and the observation group was treated with partial closure with methylene blue mixed hormone and compound betamethasone injection. Comparison were made on efficacy, disappearance time of pruritus symptoms, the complete disappearance time of skin lesions, recurrence, symptom score, 36 item short form health survey(SF-36) score before and after treatment between the two groups. Results The higher total effective rate of observation group was 100.00%, which was higher than 76.00% in the control group, and the difference was statistically significant(P<0.05). After treatment, dymptom score and SF-36 score of the two groups were better than those before treatment, and the improvement of the observation group was greater. Their difference was statistically significant(P<0.05). The disappearance time of pruritus symptoms and complete disappearance time of skin lesions in observation group were respectively(17.11±1.41) and(24.13±0.24) d, which were shorter than(23.50±2.25) and(29.23±1.51) d in the control group. Their difference was statistically significant(P<0.05). There was no significant difference in recurrence rate between the two groups(P>0.05). Conclusion Partial closure with methylene blue and compound betamethasone injection contains significant effect on the treatment of anal pruritus, and it is worthy of promotion.
作者
欧剑标
胡丰良
OU Jian-biao;HU Feng-liang(Anorectal Department, Guangzhou Baiyun District Second People's Hospital,Guangzhou 510450,China)
出处
《中国实用医药》
2019年第22期74-76,共3页
China Practical Medicine
关键词
亚甲蓝混合激素
局部封闭治疗
肛门瘙痒
可行性
Methylene blue mixed hormone
Partial closure treatment
Anal itch
Feasibility
