摘要
目的:探讨射波刀立体定向放射外科(SRS)治疗小细胞肺癌(SCLC)脑转移(BM)的有效性及安全性。方法:回顾性分析2006年7月-2015年12月期间SRS治疗的28例SCLC脑转移的患者资料,其中包括全脑放疗(WBRT)与SRS联合治疗13例,SRS挽救性治疗15例。分析总生存时间(OS)、颅内局部控制率(LC)及颅内无远处转移生存(DMFS)情况。结果:中位随访时间为13个月,中位生存期为12个月,1年、2年的OS分别为50.0%、22.2%;1年、2年的LC分别为85.4%、76.8%;6个月、1年、2年的DMFS为73.9%、66.1%、38.2%。治疗后1.5月内,1~2级急性毒副反应发生率为10%,未见3级及3级以上急性毒副反应。结论:SRS治疗SCLC脑转移患者可取得较好的生存率,并且不良反应少,是安全有效的方法。
Objective: To evaluate the efficacy and safety of CyberKnife stereotactic radiosurgery(SRS) in the treatment of patients with brain metastases (BM) from small cell lung cancer(SCLC). Methods: A group of 28 patients with brain metastases from small cell lung cancer treated with CyberKnife SRS from July 2006 to December 2015 were retrospectively studied. There were 13 cases of whole brain radiotherapy(WBRT) combined with stereotactic radiosurgery and 15 cases of salvage stereotactic radiosurgery therapy. Overall survival (OS), Local contral(LC) and Distant metastases free survival(DMFS) were analyzed to assess the efficacy. Results: In a median follow-up of 13 months, the median overall survival was 12 months, 1-and 2-year overall survivals were 50.0% and 22.2%;1-and 2-year local contral were 85.4% and 76.8%, respectively;the median time for distant metastases was 6 months, 1-and 2-year distant metastases free survivals were 66.1% and 38.2%. Within 1.5 months after treatment, the incidence of acute toxic and side effects of grade 1-2 was 10%, and no acute side effects of grade 3 or higher were observed. Conclusion: CyberKnife SRS can achieve higher survival rate and less adverse reactions in the treatment of SCLC brain metastasis, and it may be a safe and effective method.
作者
赵军华
邱鸣寒
袁智勇
ZHAO Jun-hua;QIU Ming-han;YUAN Zhi-yong(Department of Radiation Oncology and CyberKnife Center,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin Key Lanboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin 300060 China;Department of Medical Oncology,Tianjin People’s Hospital,Tianjin 300121,China)
出处
《天津医科大学学报》
2019年第4期346-350,共5页
Journal of Tianjin Medical University
关键词
小细胞肺癌
脑转移瘤
全脑放疗
射波刀立体定向放射外科
生存
small cell lung cancer
brain metastases
whole brain radiotherapy
stereotactic radiosurgery
overall survival
