摘要
目的探讨胸中段食管鳞癌(ESCC)干扰素诱导跨膜蛋白3(IFITM3)、半乳糖凝集素-7(Galectin-7)和Galectin-9表达及与改良Ivor-lewis术后淋巴结转移性复发的关系。方法改良Ivor-lewis手术治疗的胸中段食管癌病人91例,采用免疫组织化学法(IHC)检测肿瘤组织及癌旁正常组织中IFITM3、Galectin-7、Galectin-9表达情况,并分析其与术后淋巴结转移性复发的关系。结果 ESCC病灶组织中IFITM3、Galectin-7表达量高于癌旁组织,Galectin-9表达量低于癌旁组,差异有统计学意义(P<0.05);ESCC病灶组织中IFITM3、Galectin-7、Galectin-9阳性表达率分别为57.14%、65.93%和60.44%,癌旁组织分别为13.19%、5.49%和89.01%,两组比较差异有统计学意义(P<0.05)。随着TNM分期的升高,IFITM3、Galectin-7的阳性表达率也明显升高(P<0.05)。术后3年内有37例(40.66%)淋巴结复发性转移,TNM分期、IFITM3和Galectin-7过表达、Galectin-9欠表达是淋巴结转移性复发的独立危险因素(P<0.05)。结论 IFITM3、Galectin-7过表达和Galectin-9欠表达参与了胸中段ESCC的发生及发展,且与改良Ivor-lewis术后淋巴结转移性复发密切相关。
Objective To investigate the expression of interferon-induced transmembrane protein 3(IFITM3),Galectin-7 and Galectin-9 of midthoracic esophageal squamous cell carcinoma(ESCC)and relationship with lymphatic metastatic recurrence after modified Ivor-lewis esophagectomy.Methods 91 patients with midthoracic ESCC underwent modified Ivor-lewis esophagectomy with two-field lymphadenectomy were enrolled,the expression profile of IFITM3,Galectin-7,Galectin-9 protein of samples of the ESCC tissues and para-carcinoma tissues were detected by immunohistochemistry(IHC),the relationship of IFITM3,Galectin-7,Galectin-9 expression and lymphatic metastatic recurrence was analyzed.Results The expression of IFITM3 and Galectin-7 in samples of ESCC tissues was significantly higher than the para-carcinoma tissues,while the expression of Galectin-9 was significantly lower than the para-carcinoma tissues,the differences were statistically significant(P<0.05).The positive expression rate of IFITM3,Galectin-7,Galectin-9 in samples of ESCC tissues was 57.14%,65.93% and 60.44%,respectively;and the positive expression rate was 13.19%,5.49% and 89.01% in samples of para-carcinoma tissues,respectively.Tthe difference was statistically significant(P<0.05).With the increase of TNM stage,the positive expression rates of IFITM3 and Galectin-7 were significantly increased(P<0.05).There was 37 patients(40.66%)with lymphatic metastatic recurrence within 3 years after surgery,the TNM stage,IFITM3 and Galectin-7 overexpression,and Galectin-9 underexpression were independent risk factors forymphatic metastatic recurrence(P<0.05).Conclusion IFITM3,Galectin-7 overexpression and Galectin-9 underexpression might involve in occurrence and development of the midthoracic ESCC.It may be closely related to improved lymph node metastasis after Ivor-lewis surgery.
作者
孙之昀
邹志强
SUN Zhiyun;ZOU Zhiqiang(Department of Thoracic Surgery, the 960th Hospital of the Joint Logistics Support Force of Chinese People's Liberation Army,Shandong, ji'nan 250031,China)
出处
《临床外科杂志》
2019年第7期581-584,共4页
Journal of Clinical Surgery
关键词
食管鳞癌
改良Ivor-lewis手术
淋巴转移复发
干扰素诱导跨膜蛋白3
半乳糖凝集素
esophageal squamous cell carcinoma
modified Ivor-lewis esophagectomy
lymphatic metastatic recurrence
interferon-induced transmembrane protein 3
galectin
