摘要
目的探讨阿尔茨海默病患者T淋巴细胞亚群、SOD及MAD水平的变化,并与认知功能的相关性。方法分析2015年5月-2017年8月在嘉兴市康慈医院老年疾病科住院治疗的56例被诊断为阿尔茨海默病患者的临床资料,作为研究组,另选取同期健康体检的老年人60例作为对照组。分析2组T淋巴细胞亚群、SOD和MDA水平的差异及与认知功能的相关性。结果阿尔茨海默病患者的MMSE总分、CD3^+、CD8^+、SOD及SOD/MDA水平较对照组均明显降低(P <0. 001),而CD4^+、CD4^+/CD8^+、MDA水平较对照组明显增高(P <0. 001);Pearson相关分析显示,AD患者中CD3^+、CD8^+、SOD水平与MMSE评分呈正相关(r值分别为0. 273、0. 358、0. 457,P <0. 05),而CD4+、MAD水平与MMSE评分呈负相关(r值分别为-0. 317、-0. 256,P <0. 05)。结论阿尔茨海默病患者存在T淋巴细胞免疫功能紊乱、抗氧化能力降低及氧化应激损伤,T淋巴细胞亚群相关指标及SOD和MDA可能参与了AD患者认知损害的发病过程,这些指标的检测对阿尔茨海默病的诊断和预后监测有重要的临床价值。
Objective To study the changes of T lymphocyte subsets,SOD,MDA levels in patients with Alzheimer disease( AD) and explore the correlation with cognitive function. Methods The clinical data of 56 cases Alzheimer's patients for treatment in the department of senile disease of Jiaxing Kangci Hospital from May 2015 to August 2017 were analyzed,and they were selected as study group. 60 elderly people for health check-up were selected as control group. The correlation of cognitive function and T lymphocyte subsets,SOD,MDA levels of the two groups were analyzed. Results The MMSE scores and levels of CD3^+,CD8^+,SOD,SOD/MDA in patients with Alzheimer's disease depressed;the levels of CD4^+,CD4^+/CD8^+,MDA in patients with Alzheimer's disease increased,compared with control group. Pearson correlation analysis suggested that CD3^+,CD8^+ and SOD levels in patients with Alzheimer's disease had positive correlation to the MMSE scores( r = 0. 273,r = 0. 358,r = 0. 457,P 0. 05),while the levels of CD4+and MAD were negatively correlated with the MMSE scores( r =-0. 317,r =-0. 256,P 0. 05). Conclusion The patients with Alzheimer's disease are significantly correlated with T lymphocyte immune dysfunction,decrease of antioxidant capacity and oxidative stress injury. The related indicators of T lymphocyte subsets,SOD and MDA may be involved in the pathogenesis of cognitive impairment in AD patients. The detection of these indicators has important clinical value for the diagnosis and prognosis monitoring of Alzheimer's disease.
作者
查显友
周燕
CHA Xian-you;ZHOU Yan(Department of Laboratory Medicine, Kang - ci Hospital of Jiaxing, Jiaxing, Zhejiang 314500, China)
出处
《中国卫生检验杂志》
CAS
2019年第15期1851-1853,1857,共4页
Chinese Journal of Health Laboratory Technology
基金
桐乡市科技局科技项目(201403182)
