摘要
目的研究早期胰岛素治疗妊娠期糖尿病患者的临床意义,并分析其对新生儿死产率的影响。方法方便选取该院2015年12月-2017年8月收治的88例妊娠期糖尿病患者进行研讨,将其按照随机数字表法进行分组,研究组与对照组各44例,对照组患者应用盐酸二甲双胍治疗,研究组采取门冬胰岛素治疗,对比分析两组患者血糖水平(空腹血糖、餐后2 h血糖以及糖化血红蛋白)、并发症发生情况、新生儿情况,并观察两组患者的总胆固醇、总胆红素、尿酸以及尿微量蛋白指标。结果研究组并发症发生率(15.91%)显著低于对照组(36.36%)(χ^2=4.767 9,P<0.05),研究组患者空腹血糖(FBG)、餐后2 h血糖(2 hBG)以及糖化血红蛋白(HbAlc)显著低于对照组患者(t=8.714 8、18.222 0、5.266 9,P<0.05),研究组患者总胆红素水平明显高于对照组(t=6.688 9),总胆固醇、尿酸以及尿微量蛋白水平显著低于对照组(t=13.161 2、16.453 8、12.501 8,P<0.05),研究组低血糖发生率(2.27%)、黄疸发生率(4.54%)明显低于对照组(15.91%,18.18%),组间差异有统计学意义(χ^2=4.950 0、4.061 5,P<0.05),而两组在呼吸窘迫与死亡率方面差异无统计学意义(P>0.05)。结论妊娠期糖尿病患者早期应用胰岛素治疗的效果明显,不仅能够控制患者血糖水平,还能够改善母婴结局,值得临床进一步应用探索。
Objective To study the clinical significance of early insulin therapy in patients with gestational diabetes mellitus and to analyze its effect on neonatal mortality. Methods Eighty-eight patients with gestational diabetes admitted to our hospital from December 2015 to August 2017 were conveniently selected and grouped according to the random number table method. 44 patients in the study group and the control group respectively, and metformin hydrochloride in the control group,and the study group took insulin aspart, treatment of blood glucose levels(fasting blood glucose, postprandial 2 h blood glucose and glycated hemoglobin), complications, neonatal conditions, and observed the total cholesterol, total cholesterol in the two groups of patients of red pigment, uric acid and urine microprotein indicators. Results The incidence of complications in the study group(15.91%) was significantly lower than that in the control group(36.36%)(χ^2=4.767 9, P<0.05). Fasting blood glucose(FBG), postprandial 2 h blood glucose(2 hBG), and glycosylated hemoglobin in the study group.(HbAlc) was significantly lower than the control group(t=8.714 8, 18.222 0, 5.266 9,P<0.05). The total bilirubin level in the study group was significantly higher than that in the control group(t=6.688 9,P<0.05), total cholesterol, uric acid and microalbuminuria level was significantly lower than the control group(t=13.161 2, 16.453 8, 12.581 8,P<0.05). The incidence of hypoglycemia(2.27%) and the incidence of jaundice(4.54%) in the study group were significantly lower than those in the control group(15.91%, 18.18%). Obviously, there was statistical significance(χ^2=4.950 0, 4.061 5, P<0.05), while the two groups had no statistical significance in respiratory distress and mortality(P>0.05). Conclusion The early application of insulin therapy in patients with gestational diabetes is effective. It can not only control the blood glucose level of patients, but also improve the maternal and infant outcomes. It is worthy of further clinical application.
作者
李雪梅
LI Xue-mei(Department of Obstetrics and Gynecology, Caoxian Chinese Medicine Hospital, Caoxian, Shandong Province, 274000 China)
出处
《中外医疗》
2019年第21期100-102,共3页
China & Foreign Medical Treatment
关键词
妊娠期糖尿病
门冬胰岛素
空腹血糖
尿微量蛋白
糖化血红蛋白
总胆固醇
Gestational diabetes mellitus
Insulin aspart
Fasting blood glucose
Urine microprotein
Glycated hemoglobin
Total cholesterol
