摘要
目的研究糖尿病足创面感染病原菌的分布状况,以及降钙素原(PCT)和血清C反应蛋白(CRP)在糖尿病足创面感染患者诊断中的临床价值,为临床防治提供参考。方法从该院2016年1月-2018年12月诊治的糖尿病患者中方便选取90例作为研究对象。观察组45例,为糖尿病足创面感染患者;对照组45例,为单纯糖尿病患者。分析比较两组患者的PCT、 CRP水平以及患者的病原菌分布状况。结果观察组患者的PCT水平(4.82±0.13)μg/L明显高于对照组(0.17±0.04)μg/L,CRP水平(65.69±5.87)mg/L明显高于对照组(16.74±3.62)mg/L,两组比较差异有统计学意义(t=3.759 4、4.257 3,P<0.05);糖尿病足创面感染患者Wagner分级5级的PCT水平(11.04±2.52)μg/L明显高于1级患者(1.09±0.97)μg/L;Wagner分级5级患者的CRP水平(34.36±2.72)mg/L明显高于1级患者(12.98±3.84)mg/L,Wagner各级别比较差异有统计学意义(t=3.856 2、4.748 3,P<0.05);在糖尿病足创面感染中分离出的病原菌,有革兰阴性菌26株(42.63%),革兰阳性菌29株(47.54%),真菌6株(9.84%)。结论糖尿病足感染患者的PCT、CRP水平明显升高,并且不同Wagner分级患者的PCT、CRP水平随着级别升高而升高。革兰阴性菌和革兰阳性菌是糖尿病足创面感染的主要致病菌。在糖尿病足感染的诊断中CRP和PCT可以作为重要依据,具有一定的临床价值,值得广泛应用。
Objective To study the distribution of pathogenic bacteria in diabetic foot wounds and the clinical value of procalcitonin(PCT) and serum C-reactive protein(CRP) in the diagnosis of diabetic foot wound infection, and provide reference for clinical prevention and treatment. Methods 90 patients from our hospital from January 2016 to December 2018 were convenient selected as subjects. 45 patients in the observation group were infected with diabetic foot wounds;45 patients in the control group were diabetic patients. The PCT and CRP levels and the distribution of pathogens in the patients were compared and analyzed. Results The PCT level(4.82±0.13)μg/L in the observation group was significantly higher than that in the control group(0.17±0.04)μg/L, and the CRP level(65.69±5.87) mg/L was significantly higher than the control group(16.74±3.62) mg/L, the difference between the two groups was statistically significant(t=3.759 4, 4.257 3, P<0.05);the PCT level(11.04±2.52)μg/L of Wagner grade 5 patients with diabetic foot wound infection was significantly higher than that of grade 1 patients of(1.09±0.97)μg/L;the CRP level of the Wagner grade 5 patients(34.36±2.72) mg/L was significantly higher than that of the grade 1 patients(12.98±3.84) mg/L, and the Wagner grades were statistically significant(t=3.856 2, 4.748 3, P<0.05);pathogens isolated from diabetic foot wound infection, 26 strains of Gram-negative bacteria(42.63%), 29 strains of Gram-positive bacteria(47.54%), and 6 strains of fungi(9.84%). Conclusion The levels of PCT and CRP in patients with diabetic foot infection are significantly increased, and the levels of PCT and CRP in patients with different Wagner grades increase with the increase of grade. Gram-negative bacteria and Gram-positive bacteria are the main pathogens of diabetic foot wound infection. CRP and PCT can be used as important basis in the diagnosis of diabetic foot infection, which has certain clinical value and is worthy of wide application.
作者
杨明妍
YANG Ming-yan(Department of Endocrinology, Beihai People's Hospital, Beihai, Guangxi, 536000 China)
出处
《中外医疗》
2019年第21期167-169,共3页
China & Foreign Medical Treatment
关键词
糖尿病足感染
C反应蛋白
降钙素原
病原菌
Diabetic foot infection
C-reactive protein
Procalcitonin
Pathogen
