摘要
2型糖尿病(T2DM)在全球范围内广泛流行,其主要特征为胰岛素抵抗和胰腺β细胞分泌的胰岛素减少,糖脂代谢发生紊乱,其发病原因是多因素的。单磷酸腺苷(adenosine monophosphate,AMP)激活的蛋白激酶(AMP-activated protein kinase,AMPK)和过氧化物酶增殖物激活受体(peroxisome proliferater-activated receptors,PPARs)作为体内代谢过程的关键调节因子,对糖脂代谢平衡有着巨大贡献。本文着重综述两者在2型糖尿病发生发展中的作用机制,以及相应的药物对2型糖尿病的治疗效果和作用机制,以期为2型糖尿病药物的研发提供参考。
Type 2 diabetes mellitus (T2DM) is a major epidemic worldwide which features insulin resistance and decreased insulin secretion from pancreatic β cells,causing disorders of glycolipid metabolism.The pathogenesis of the disease is multifactorial.AMPK and PPARs,as key regulators of metabolic processes in the body,contribute significantly to the balance of glycolipid metabolism.This article focuses on the mechanism of the above-mentioned regulators in the development of T2DM and the therapeutical effect and mechanism of corresponding drugs,in order to provide reference for the development of T2DM drugs.
作者
丁婕
傅继华
DING Jie;FU Jihua(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《药学研究》
CAS
2019年第8期477-480,489,共5页
Journal of Pharmaceutical Research
基金
国家自然科学基金(No.81570720)
