摘要
目的系统评价老年高血压患者衰弱现状及影响因素.方法计算机检索The Cochrane Library、PubMed、EMbase、Web of Science、中国生物医学文献数据库(CBM)、CNKI、维普中文期刊数据库(VIP)及万方数据库中关于老年高血压患者衰弱发生率及影响因素的相关文献,检索时限为建库至2018年12月31日.采用RevMan5.3软件进行Meta分析.结果共纳入16篇文献,其中14篇横断面研究,2篇队列研究,老年高血压患者合计11799例.Meta分析结果显示,纳入研究间异质性较大(I2=99%,P<0.01),基于随机效应模型老年高血压患者的合并衰弱发生率为32%(95%CI:21%,43%).影响老年高血压患者衰弱发生的主要因素为年龄[OR=1.32,(95%CI:1.09,1.59)]、BMI异常[OR=0.84,(95%CI:0.28,2.54)]、文化程度[OR=4.48,(95%CI:1.59,12.63)]、合并糖尿病[OR=1.84,(95%CI:1.27,2.67)]以及多重用药[OR=4.09,(95%CI:0.28,60.06)].结论老年高血压患者衰弱发生率较高,导致其衰弱的原因较多.但纳入研究多为横断面研究且数量有限,论证强度存在不足,尚需更多高质量研究予以验证.
Objective To systematically review the current status of frailty and its influencing factors in elderly hypertension patients. Methods Articles about the incidence and influencing factors of frailty in elderly hypertensive patients were retrieved from the established date of databases to 31st, December of 2018 in electronic databases such as Cochrane Library, PubMed, EMbase, Web of Science , CBM , CNKI , VIP and Wanfang database and then RevMan5.3 statistic software was used in meta analysis. Results Totally 16 articles were included involving 14 cross-sectional studies, 2 cohort studies, and 11 799 elderly hypertensive patients. Meta-analysis result indicated that, between-study heterogeneity detected was significant (I2=99%, P<0.01), the pooled incidence based on random-effect model was 32%(95%CI: 21%, 43%). The main influencing factors of frailty in elderly hypertensive patients were age [OR=1.32,(95%CI: 1.09, 1.59)], abnormal BMI [OR=0.84,(95%CI: 0.28, 2.54)], educational level [OR=4.48,(95%CI: 1.59, 12.63)], comorbidity of diabetes [OR=1.84,(95%CI: 1.27, 2.67)]and polypharmacy[OR=4.09,(95%CI: 0.28, 60.06)]. Conclusions There is a high incidence of frailty in elderly hypertensive patients led by a variety of causes. However, the majority of studies included were cross-sectional studies and the number was limited with not enough argument, more researches with high quality are needed to evaluate the result.
作者
冷雅楠
李玉琦
刘婷婷
庞晓丽
Leng Yanan;Li Yuqi;Liu Tingting;Pang Xiaoli(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Nursing,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China)
出处
《中华现代护理杂志》
2019年第20期2545-2550,共6页
Chinese Journal of Modern Nursing
基金
天津市教委重点项目(171006301C).
