摘要
目的探索苹果酸奈诺沙星胶囊在慢性骨感染口服序贯治疗中的疗效及安全性。方法在诊断为葡萄球菌属致病的慢性骨感染患者中选择适合的病例,在清创术后抗感染治疗中使用苹果酸奈诺沙星胶囊进行单药口服序贯治疗,通过随访骨感染的复发来观察疗效,并记录不良反应。结果从2018年1月至2019年5月,共有10例诊断为慢性骨感染的患者入选,其中男性9例,女性1例,平均年龄(45.40±11.61)岁(32~68岁),感染部位胫骨5例,踝关节3例,足部2例;10例均术中采样微生物鉴定结果为葡萄球菌属;10例患者均经过清创手术,术后均经过7~14 d的静脉抗感染治疗,后续序贯治疗中均口服苹果酸奈诺沙星胶囊平均(23.40±8.34)d(9~30 d)。平均随访(6.40±3.37)个月(2~14个月),10例患者骨感染均未复发,且未发现任何不良反应。结论苹果酸奈诺沙星胶囊在葡萄球菌属致慢性骨感染口服序贯治疗中有良好的疗效和耐受性,值得在临床中进一步推广应用。
Objective This study was designed to explore the efficacy and safety of nemonoxacin malate capsule in the oral sequential treatment of chronic bone infections.Methods Select suitable cases among the patients with chronic bone infection diagnosed as staphylococcus.Nemonoxacin malate capsule was used in the anti-infection treatment after debridement.The curative effect was observed by following up the recurrence of bone infection,and adverse reactions were recorded.Results From January 2018 to May 2019,10 patients with chronic bone infections were selected,including 9 males and 1 female,with an average age of (45.40±11.61) years(32-68 years),5 tibial infections,3 ankle infections and 2 foot infections.10 patients were identified as suffering from staphylococcus during operation.10 patients underwent debridement,and all underwent intravenous antibiotics for 7-14 days after operation.Nemonoxacin malate capsules were administered orally for an average of (23.40±8.34) days(9-30 days). The average follow-up period was (6.40±3.37) months(2-14 months). Bone infections in 10 patients did not recur and no side effects were found.Conclusion Nemonoxacin malate capsule has good efficacy and tolerance in oral sequential treatment of chronic staphylococcal bone infections,and it is worth further exploring in clinical practice.
作者
陈辉
尹凯
张琮
杜伟力
胡骁骅
沈余明
CHEN Hui;YIN Kai;ZHANG Cong;DU Wei-li;HU Xiao-hua;SHEN Yu-ming(Department of Burns and Plastic Surgery,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Infection Control/Department of Disease Control,Beijing Jishuitan Hospital,Beijing 100035,China)
出处
《临床药物治疗杂志》
2019年第7期23-26,45,共5页
Clinical Medication Journal
关键词
慢性骨感染
苹果酸奈诺沙星胶囊
口服序贯
chronic bone infection
nemonoxacin malate capsule
oral sequential
