摘要
目的研究帕罗西汀配合高频重复经颅磁刺激(rTMS)治疗老年抑郁症的临床疗效及对认知功能的影响.方法选取2017年6月至2018年6月期间收治的老年抑郁症90例,按照随机数表法将其分为联合组、帕罗西汀组和高频rTMS组,每组各30例.高频rTMS组给予高频rTMS治疗,帕罗西汀组给予帕罗西汀治疗,联合组给予帕罗西汀联合高频rTMS治疗.统计并对比三组治疗前后汉密尔顿抑郁量表(HAMD)评分、临床疗效、治疗前后简明精神状态检查(MMSE)评分以及治疗期间不良事件发生情况.结果三组治疗后HAMD评分均显著降低(P<0.05),且治疗后联合组HAMD评分与帕罗西汀组、高频rTMS组比较显著较低(P<0.05);联合组总有效率显著高于帕罗西汀组、高频rTMS组(P<0.01);治疗后三组MMSE总分、定向力、语言能力、记忆力、注意力和计算力评分均显著高于治疗前(P<0.05),且三组比较,治疗后联合组上述各项评分均显著高于帕罗西汀组、高频rTMS组(P<0.05).三组比较,总不良事件发生率差异均不显著(P>0.05).结论帕罗西汀、高频rTMS治疗老年抑郁症均能减轻临床症状,改善认知功能,二者联合作用的效果更佳,且不会显著增加不良事件发生率.
Objective To study the clinical efficacy and the influence on cognitive function of paroxetine combined with high frequency repetitive transcranial magnetic resonance(rTMS)in the treatment of senile depression. Methods 90 patients with depression who were treated in hospital from June 2017 to June 2018 were randomly divided into combination group,paroxetine group and high frequency rTMS group with 30 cases in each group. The high frequency rTMS group were given high frequency rTMS therapy,the paroxetine group were treated with paroxetine treatment, while the combined group were given paroxetine combined with high frequency rTMS therapy. The hamilton depression scale(HAMD)score was compared between the 3 groups before and after treatment. The clinical efficacy of the 3 groups were compared. The brief mental state examination score (MMSE)were compared between the 3 groups before and after treatment. The adverse reactions were compared between the 3 groups during treatment. Results After treatment,the HAMD scores of the 3 groups were significantly lower(P<0.05),and the HAMD scores of the combined group were significantly lower than those of the paroxetine group and the high frequency rTMS group(P<0.05). The total effective rate of the combined group was significantly higher than that of the paroxetine group and the high frequency rTMS group(P<0.01). After treatment,the scores of MMSE, orientation,language ability,memory,attention and computational ability in the 3 groups were significantly higher than those before treatment (P<0.05),and the above scores of the combined group were significantly higher than those of the paroxetine group and the high frequency rTMS group(P<0.05). There was no significant difference in the incidence of total adverse events between the 3 groups(P>0.05). Conclusion Paroxetine and high-frequency rTMS can alleviate clinical symptoms and improve cognitive function in the treatment of senile depression,of which the combination effect is better and it will not significantly increase the incidence of adverse events.
出处
《浙江临床医学》
2019年第8期1083-1085,共3页
Zhejiang Clinical Medical Journal
关键词
帕罗西汀
高频重复经颅磁治疗
老年抑郁症
认知功能
Paroxetine
High frequency repetitive transcranial magnetic therapy
Senile depression
Cognitive function
