摘要
目的 通过交叉配血次侧不合发现不规则抗体筛查阳性的献血者并鉴定不规则抗体特异性,保障输血安全。方法通过交叉配血次侧均不相合且复查血型发现不规则抗体筛查阳性的献血者,并鉴定抗体特异性;将其中4袋不规则抗体筛查阳性的悬浮红细胞制备为洗涤红细胞,并跟踪其输注效果。结果 2016年11月至2017年12月期间,34297例献血者中发现11例为不规则抗体筛查阳性,其中抗-E5例、抗-M4例、自身抗体1例、非特异性抗体1例。两名患者输注抗筛阳性洗涤红细胞后,输注有效,无不良输血反应发生。结论 常规开展献血者不规则抗体筛查项目具有重要的临床意义,将抗筛阳性的悬浮红细胞制备为洗涤红细胞,可以保障输血安全,节约血液资源。
Objective The blood donors with negative antibody screening results were found by cross- matching and the irregular antibody specificity was identified,so to guarantee the blood transfusion safety. Methods By reviewing the blood types and the cross- matching results of the secondary side,the irregular antibody- positive blood donors were found and the antibody specificity was identified.4 bags of anti- screening suspended red blood cells were prepared and delivered as the washed red blood cells to the clinic,and the effect of infusion was followed and evaluated. Results From November,2016 to December,2017,11 of 34297 blood donors were found to be screen- positive,including 5 cases of anti- E,4 cases of anti- M,1 case of autoantibodies and 1 case of non- specific antibody.Two patients were infused with anti- sieving positive washing red blood cells,the effect of transfusion was significant and no adverse transfusion reaction occurred. Conclusion It is recommended to routinely conduct blood donor irregular antibody screening programs to ensure blood transfusion safety,and prepare anti- sieving suspension red blood cells to wash red blood cells,in order to save blood resources.
作者
台胜飞
马春娅
赵嫚
于洋
汪德清
TAI Sheng-fei;MA Chun-ya;ZHAO Man;YU Yang;WANG De-qing(Department of Blood Transfusion,Chinese PLA General Hospital,Beijing 100853,China)
出处
《标记免疫分析与临床》
CAS
2019年第8期1261-1264,共4页
Labeled Immunoassays and Clinical Medicine
基金
十三五全军后勤科研重点项目子课题(编号:BWS16J006)
关键词
献血者
不规则抗体
洗涤红细胞
Blood donor
Irregular antibody
Washing red blood cell
