摘要
目的:观察清肝补肺组方联合雷公藤多苷治疗强直性脊柱炎相关性前葡萄膜炎患者的临床疗效以及其对炎症相关指标的影响。方法:选取符合标准的前葡萄膜炎患者60例,随机平均分为2组,对照组30例患者在散瞳、糖皮质激素、非甾体类药物等常规治疗方法的基础上加用雷公藤多苷片治疗,观察组30例患者在对照组治疗的基础上加用清肝补肺组方治疗,2组患者均以2周为1疗程,治疗1个疗程后统计2组患者的红细胞沉降率(ESR)、和肿瘤坏死因子-α(TNF-α)指标以及临床疗效与不良反应。结果:对照组的总有效率为43.3%,观察组的总有效率为90.00%,经χ2检验,观察组的总有效率显著高于对照组(P<0.05)。观察组患者治疗后炎症评分、ESR及TNF-α指标明显低于治疗前及对照组治疗后(P<0.05)。结论:清肝补肺组方联合雷公藤多苷片治疗AS相关性前葡萄膜炎患者,可以有效降低血清炎症指标,改善患者免疫状态,提高临床疗效,减轻患者痛苦,具有良好的临床效果。
Objective: To study efficacy of Qinggan Bufei decoction combined with ripterygium polyglycosides in the treatment of ankylosing spondylitis associated with anterior uveitis and its effect on inflammatory indicators. Methods: To choose between January 2016 and December 2018 in Henan province hospital of traditional Chinese medicine ophthalmology of 60 patients with anterior uveitis, randomly divided into 2 groups, control group 30 cases on the basis of routine treatment plus with ripterygium polyglycosides tablets treatment, the observation group of 30 patients on the basis of the control group therapy combined with Qinggan Bufei decoction treatment, Patients in both groups received a course of treatment of 2 weeks, treatment after a course of statistics of two groups patients’ erythrocyte sedimentation rate (ESR), and tumor necrosis factor alpha (TNF alpha)index and the clinical curative effect and adverse reactions. Results: The total efficiency was 43.3% in the control group, lower than 90.00% in the observation group (P<0.05). Inflammatory scores, ESR and TNF-α in the observation group were significantly lower than those before and after treatment (P<0.05). Conclusion: Qinggan Bufei decoction combined with ripterygium polyglycoside tablets in the treatment of AS related anterior uveitis patients can effectively improve serum inflammatory indicators, but also improve the immune status of patients, with good clinical effect.
作者
孟凡超
杨二双
张凤梅
MENG Fanchao;YANG Ershuang;ZHANG Fengmei(Henan University of Chinese Medicine, Henan Zhengzhou 450046, China;Henan Province Hospital of Traditional Chinese Medicine, Henan Zhengzhou 450002, China)
出处
《中医药临床杂志》
2019年第8期1518-1521,共4页
Clinical Journal of Traditional Chinese Medicine
关键词
清肝补肺方
前葡萄膜炎
强直性脊柱炎
雷公藤多苷片
临床疗效
Qinggan Bufei decoction
Anterior uveitis
Ankylosing spondylitis
Tripterygium polyglycoside tablet
Clinical efficacy
