摘要
免疫性血小板减少症(ITP)是一种获得性自身免疫性出血性疾病,虽然ITP病因至今未明,但就目前的观点而言,免疫失耐受为ITP发病的主要原因。除却经典的免疫发病机制外,近年来更多的免疫细胞亚群、细胞因子及新的作用途径被发现与ITP的发生密切相关,包括去唾液酸化、B细胞激活因子作用、调节性B细胞功能异常、Th1/Th2平衡漂移、CD4^+CD25^+T细胞功能缺陷、IL-23/Th17途径调控等。本文就此对ITP免疫发病机制的最新研究进展作一综述,为更加深入认识ITP发病机制及研究方向提供理论依据。
Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease,although the ITP pathogenesis is completely unknown,but in terms of the current view,the immune tolerance is main reason for the onset of ITP. In recent years,more and more immune cell subsets,cytokines and the new approacher were found to be closely related with the ITP,such as saliva acid,B cell activating factor,dysfunction of regulatory B cells and Th1/ Th2 balance drift,CD4^+ CD25^+ T cell function defect,IL-23/ Th17 pathway regulation,etc.,In this paper,the latest research progress on the immune pathogenesis of ITP are reviewed,so as to provide theoretical basis and research direction for further understanding the pathogenesis of ITP.
作者
黄炜祺
周咏明
HUANG Wei-Qi;ZHOU Yong-Ming(Department of Hematology,The Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430064,Hubei Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2019年第4期1321-1324,共4页
Journal of Experimental Hematology
基金
国家自然科学基金资助项目(编号81373302)
