摘要
目的:观察吗啡通过两种不同途径治疗癌痛的效果以及安全性。方法:选取80例中晚期癌痛患者为研究对象。按照简单随机化法将患者分为观察组和对照组各40例。对照组口服吗啡,观察组皮下注射吗啡,均给药3次。比较两组患者疼痛缓解有效率、疼痛缓解的起效时间和最佳时间,以及患者并发症发生率。结果:观察组治疗有效率为95.0%(38/40),略高于对照组的90.0%(36/40),差异无统计学意义(P>0.05);观察组镇痛起效时间和最佳缓解时间明显优于对照组,差异有统计学意义(P<0.05);分别评定给药3次后VAS评分,观察组均明显低于对照组,差异具有统计学意义(P<0.01);观察组不良反应发生率为30.0%(12/40),与对照组的37.5%(15/40)比较,差异无统计学意义(P>0.05)。结论:皮下注射吗啡对癌痛患者的镇痛效果好,起效时间快,安全性比较高。
Objective:To study effects and safety of two different routes of Morphine analgesia in patients with cancer pain.Methods:80 patients with advanced cancer pain were selected as the study subjects.According to the simple randomization method,these patients were divided into observation group and control group,40 cases in each.The control group received oral Morphine,while the observation group received subcutaneous injection of Morphine.The effective rate of pain relief,the onset time and optimal time of pain relief,and the incidence of complications were compared between the two groups.Results:The effective rate of the observation group was 95.0%(38/40),which was slightly higher than that of the control group(90.0%,36/40),and the difference was not statistically significant(P>0.05).The onset time and optimal time of pain relief of the observation group were significantly better than those of the control group,and the differences were statistically significant(P<0.05).The VAS score of the observation group was significantly lower than that of the control group after three doses,and the differences were statistically significant(P<0.05).The incidence rates of adverse reactions of the observation group and the control group were 30.0%(12/40)and 37.5%(15/40),respectively,and the difference was not statistically significant(P>0.05).Conclusions:For the patients with cancer pain,subcutaneous injection of Morphine can obtain a good analgesic effect with early onset and higher safety.
作者
李果
LI Guo(Two-way Referral Office of Nanyang Central Hospital,Nanyang 473000 Henan,China)
出处
《中国民康医学》
2019年第13期134-136,共3页
Medical Journal of Chinese People’s Health
关键词
癌痛
吗啡
镇痛
安全性
Cancer pain
Different routes of Morphine analgesia
Safety
