摘要
目的:探讨2型糖尿病(T2DM)病人血清甲状腺激素(TH)和促甲状腺激素(TSH)水平变化及其影响因素。方法:选取T2DM病人75例(T2DM组)及同期健康体检者75名(对照组),比较2组血清TH和TSH水平;另将T2DM组按性别、年龄、病程、糖化血红蛋白(HbA1c)、空腹血糖(FBG)进行划分,比较血清TH和TSH水平。结果:T2DM组病人血清游离三碘甲状腺原氨酸(FT3)水平明显低于对照组(P<0.01),2组游离甲状腺素(FT4)和TSH水平差异无统计学意义(P>0.05)。不同性别、是否服用二甲双胍T2DM病人的血清FT3、FT4和TSH水平差异均无统计学意义(P>0.05);不同年龄段和病程病人间的FT3水平差异均有统计学意义,随年龄和病程增加,FT3水平降低(P<0.05~P<0.01);不同HbA1c病人间的FT3、FT4水平差异均有统计学意义,随HbA1c升高,FT3、FT4水平均降低(P<0.05~P<0.01);FBG≥7.0 mmol/L病人的FT3、FT4水平均明显低于FBG<7.0 mmol/L病人(P<0.01)。Spearman相关分析显示,T2DM病人FT3水平与年龄、病程、HbA1c、FBG均呈负相关关系(P<0.05);FT4与HbA1c、FBG呈负相关关系(P<0.05)。结论:与健康成人比较,T2DM病人存在甲状腺功能异常情况,主要表现为FT3降低;T2DM病人的FT3水平变化与年龄、病程、HbA1c和FBG密切相关。
Objective:To investigate the changes of serum thyroid hormone(TH)and thyroid stimulating hormone(TSH)levels in patients with type 2 diabetes mellitus(T2 DM)and their influencing factors.Methods:Seventy-five patients with T2 DM(T2 DM group)and 75 healthy persons(control group)were selected to compare the levels of TH and TSH in serum of the two groups.The levels of TH and TSH in serum of the two groups were also compared according to sex,age,course of disease,HbAlc and FBG.Results:The level of serum free triiodothyronine(FT3)in patients with T2 DM was significantly lower than that in control group(P<0.01).There was no significant difference in the levels of free thyroxine(FT4)and TSH between the two groups(P>0.05).There was no significant difference in serum FT3,FT4 and TSH levels between different sexes,taking metformin of not in T2 DM patients(P>0.05).There were significant differences in serum FT3 levels between patients of different age groups and course of disease.With the increase of age and course of disease,the level of FT3 decreased(P<0.05 to P<0.01).There were statistical differences in FT3 and FT4 levels between patients with different HbAlc.The levels of FT3 and FT4 decreased with the increase of HbAlc(P<0.05 to P<0.01),and the levels of FT3 and FT4 in patients with FBG≥7.0 mmol/L were significantly lower than those in patients with FBG<7.0 mmo/L(P<0.01).Spearman correlation analysis showed that FT3 level was negatively correlated with age,course of disease,HbAlc and FBG in patients with T2 DM(P<0.05),and FT4 was negatively correlated with HbAlc and FBG(P<0.05).Conclusions:Compared with healthy adults,patients with T2 DM have abnormal thyroid function,which is mainly manifested by the decrease of FT3.The changes of FT3 level in patients with T2 DM are closely related to age,course of disease,HbA1 c and FBG.
作者
朱晶洁
吴磊
吕高友
葛荣靖
ZHU Jing-jie;WU Lei;LU Gao-you;GE Rong-jing(Department of Endocrinology,The Sencond Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233040;Department of Imaging,The Sencond Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233040;Department of Pathophysiology,Bengbu Medical College,Bengbu Anhui 233030,China)
出处
《蚌埠医学院学报》
CAS
2019年第6期752-755,共4页
Journal of Bengbu Medical College
