摘要
目的观察中医传统功法联合培土化毒方及SOX方案治疗结直肠癌的疗效及安全性。方法将2018年1月~12月在辽宁中医药大学附属三院就诊诊断为晚期结直肠癌的患者80例,随机分为对照组与治疗组,每组40例。对照组予SOX方案,治疗组在此基础上采用中药处方联合中医传统功法治疗。比较两组肿瘤病灶进行评价、中医症状评分、体力状况评分、观察近期疗效及安全性指标。结果治疗组有效率为35.00%,临床获益率82.50%,分别高于对照组的32.50%、80.00%,差异无统计学意义(P>0.05)。治疗组总有效率为65.00%,高于对照组的42.50%,治疗组治疗前后中医症状积分比较,统计学意义均显著(P<0.01);对照组治疗前后比较,差异无统计学意义(P>0.05);治疗后治疗组中医症状积分低于对照组,统计学意义显著(P<0.01);治疗后治疗组KPS评分高于对照组,统计学意义显著(P<0.01);两组治疗期间无死亡病例,主要的不良反应为骨髓抑制、消化道反应以及末梢神经炎等。两组白细胞减少分度比较,统计学意义显著(P<0.01);在恶心呕吐分度比较,差异有统计学意义(P<0.05);治疗组其它毒性反应发生率均较对照组低,但差异均无统计学意义(P>0.05)。结论中医传统功法联合培土化毒方及SOX方案治疗结直肠癌能改善患者症状,减轻化疗不良反应,提高生活质量。
Objective To observe the efficacy and safety of traditional Chinese medicine combined with Peifang Huadu Decoction and SOX regimen in the treatment of colorectal cancer.Methods 80 patients with advanced colorectal cancer who were diagnosed in the Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January to December 2018 were randomly divided into control group and treatment group,with 40 cases in each group.The control group was given the SOX regimen,and the treatment group was treated with traditional Chinese medicine prescription combined with traditional Chinese medicine.The tumor lesions of the two groups were compared,TCM symptom scores,physical status scores,and short-term efficacy and safety indicators were observed.Results The effective rate of the treatment group was 35.00%,and the clinical benefit rate was 82.50%,which was higher than 32.50%and 80.00%of the control group,respectively,the difference was not statistically significant(P>0.05).The total effective rate of the treatment group was 65.00%,which was higher than that of the control group 42.50%.The scores of TCM symptom scores before and after treatment in the treatment group were statistically significant(P<0.01).There was no significant difference between the control group and the control group(P>0.05);The score of TCM symptom in the treatment group was lower than that in the control group after treatment,the statistical significance was significant(P<0.01);the KPS score of the treatment group was higher than that of the control group after treatment,the statistical significance was significant(P<0.01);There were no deaths during the treatment period.The main adverse reactions were myelosuppression,digestive tract reaction and peripheral neuritis.The difference of leukopenia between the two groups was statistically significant(P<0.01).The difference in nausea and vomiting was statistically significant(P<0.05).The incidence of other toxic reactions in the treatment group was lower than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion Traditional Chinese medicine combined with Peihua Huadu Decoction and SOX regimen can improve the symptoms of patients with colorectal cancer,reduce the adverse reactions of chemotherapy and improve the quality of life.
作者
崔爱惠
张新安
路越
CUI Ai-hui;ZHANG Xin-an;LU Yue(School of Sports Human Science,Shenyang Sport University,Shenyang 110102,Liaoning,China;Liaoning Vocational College of Medicine,Shenyang 110101,Liaoning,China;the Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110003,Liaoning,China)
出处
《医学信息》
2019年第17期5-8,共4页
Journal of Medical Information
关键词
传统功法
培土化毒方
SOX方案
结直肠癌
Traditional exercises
Peifanghuadufang
SOX regimen
Colorectal cancer
