摘要
目的:探讨妊娠期糖尿病(GDM)与甲状腺功能减退的相关性。方法:选取2014年7月~2017年7月在某院进行定期产检孕妇,其中GDM孕妇65例(A组),妊娠期甲状腺功能减退者65例(B组),GDM合并甲状腺功能减退者62例(C组),随机选取同期产检正常的孕妇70例为对照组,比较各组甲状腺功能促甲状腺激素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)以及血浆D-二聚体、纤维蛋白原(FIB)的含量。结果:A组、B组和C组的FIB和D-二聚体均高于对照组,B组、C组FIB和D-二聚体均高于A组,且C组FIB和D-二聚体均高于B组,差别均有统计学意义(P<0.05);在GDM合并甲状腺功能减退患者中,血浆FIB(r=0.534,P=0.002)和D-二聚体(r=0.519,P=0.003)均与TSH呈正相关,血浆FIB(r=-0.443,P=0.014)和D-二聚体(r=-0.511,P=0.004)均与FT4呈负相关(P<0.05;P<0.01),而与FT3均无明显相关性(P>0.05)。结论:GDM患者血浆纤维蛋白原、D-二聚体异常升高与甲状腺功能减退密切相关。
Objective: To explore the correlation between gestational diabetes mellitus (GDM) and hypot-hyroidism during pregnancy. Methods: Pregnant women with regular prenatal examination in a hospital from July 2014 to July 2017 were selected, among them, 65 pregnant women with GDM (group A), 65 pregnant women with hypothyroidism (group B), and 62 pregnant women with GDM combined with hypothyroidism (group C) and 70 healthy pregnant women (control group) were enrolled into our study. The contents of thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), plasma D-dimer and fibrinogen (FIB) in each group were compared. Results: FIB and D-dimer in group A, group B and group C were higher than those in control group, meanwhile, FIB and D-dimer of group B and group C were higher than those of group A, and FIB and D-dimer of group C were higher than those of group B, with statistically significant differences ( P <0.05);In the patients with GDM combined with hypothyroidism, plasma FIB( r =0.534, P =0.002) and D-dimer ( r =0.519, P =0.003) were positively correlated with TSH, plasma FIB( r =-0.443, P =0.014) and D-dimer ( r =-0.511, P =0.004) were negatively correlated with FT4 ( P < 0.05;P <0.01), but there was no significant correlation with FT3 ( P >0.05). Conclusion: Abnormal increasing of plasma fibrinogen and D-dimer in GDM patients is closely related to hypothyroidism.
作者
郑益雪
沈飞霞
Zheng Yixue(Wenzhou Medical University,Wenzhou 325000)
出处
《数理医药学杂志》
2019年第9期1294-1296,共3页
Journal of Mathematical Medicine
