摘要
急性一氧化碳中毒是我国冬春季节的常见病、多发病,具有很高的致残率和致死率。迟发型脑病是其假愈期后的严重后遗症,机制复杂,包括环境与遗传因素、缺氧及能量代谢障碍、细胞毒性及氧自由基损伤、免疫失调及炎症激活、神经递质紊乱、大脑实质改变、血管及血液流变学异常、钙超载及细胞凋亡等。目前,预测急性一氧化碳中毒迟发型脑病发生的方法包括详细询问病史、相关指标的实验室检查、脑电生理检查、脑影像学检查和评分量表预估等。该文总结了急性一氧化碳中毒迟发型脑病的发病机制和发病早期预测方法的相关研究现状,以期为今后的研究方向提供参考借鉴。
Acute carbon monoxide poisoning is a common and frequently occurring disease in winter and spring in China, with high disability and mortality. Delayed encephalopathy is a serious sequela after the pseudo-convalescence. Its mechanism is complex, including environmental and genetic factors, hypoxia and energy metabolism disorder, cytotoxicity and oxygen free radical damage, immune disorder and inflammatory activation, neurotransmitter disorder, brain parenchymal changes, vascular and hemorheological abnormalities, calcium overload, and cell apoptosis. At present, methods for predicting delayed encephalopathy in acute carbon monoxide poisoning include detailed inquiry of medical history, laboratory examination of relevant indicators, electrophysiological examination, brain imaging examination, and evaluation scale prediction. This review summarizes the research status of the pathogenesis and early prediction methods of delayed encephalopathy in acute carbon monoxide poisoning, with a view to providing reference for future research directions.
作者
熊书艺
钟鸣
胡青
何曼
谢明欣
刘世平
XIONG Shuyi;ZHONG Ming;HU Qing;HE Man;XIE Mingxin;LIU Shiping(Department of Emergency Medicine,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,P. R. China)
出处
《华西医学》
CAS
2019年第9期1075-1080,共6页
West China Medical Journal
基金
四川省卫生和计划生育委员会重点课题(17ZD016)
关键词
急性一氧化碳中毒
迟发型脑病
发病机制
早期预测
Acute carbon monoxide poisoning
Delayed encephalopathy
Pathogenesis
Early prediction
