摘要
喹啉类化合物是一类重要的医药及农药中间体。目标化合物的合成方法目前无文献报道,以3,4-二甲基苯胺、水合氯醛和盐酸羟胺为起始原料,经酰胺化、环合、普菲青格反应和脱羧4步反应首次合成目标化合物,其结构经1HNMR、13CNMR和MS确证。路线具有原料廉价易得、反应条件温和、操作简单、后处理方便且收率较高等优点,适合工业化生产。
Quinoline compounds were an important class of pharmaceutical and pesticide intermediates. The synthetic route of target compound has not been reported in the literature. Target compounds were first synthesized based on 3,4-dimethylaniline,chloral hydrate and hydroxylamine hydrochloride by means of four steps of amidation,cyclization,Pfitzinger reaction and decarboxylation.The structure was confirmed by1 HNMR,13CNMR and MS.It is easy to operate and control the reaction and the reaction conditions were mild and the yield was higher in each step with the convenient post-processing,which is suitable for industrial production.
作者
马兰兰
罗大礼
乐意
黄筑艳
MA Lan-lan;LUO Da-li;LE Yi;HUANG Zhu-yan(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China;Guizhou Engineering Laboratory for Synthetic Drugs,Guizhou University,Guiyang 550025,China)
出处
《化学试剂》
CAS
北大核心
2019年第9期987-990,共4页
Chemical Reagents
基金
贵州省科技计划项目(黔科合LH字[2016]7422号)
贵州大学青年教师科研基金项目(贵大自青基合字[2013]07号)
