摘要
抗凝血酶Ⅲ(AT-Ⅲ)是由肝脏和血管内皮细胞分泌的一种单链糖蛋白,半衰期为2.69 d,属于广谱丝氨酸蛋白抑制物家族中的重要成员之一。AT-Ⅲ在人体内起重要的抗凝调节作用,约占血浆抗凝系统总活性的70%~80%,参与维系体内凝血系统与抗凝血系统的动态平衡,同时也是高凝状态评估的良好指标。近年来,儿科医生发现AT-Ⅲ的活性检测在评估儿童血栓形成、脓毒症及肾病综合征等方面都有非常好的临床价值。该文主要针对影响儿童抗凝血酶Ⅲ活性检测的因素分析作一综述。
Antithrombin Ⅲ(AT-Ⅲ)is a single chain glycoprotein secreted by liver and vascular endothelial cells with a half-life of 2.69 days and is one of the important members of the broad-spectrum serine protein inhibitor family.AT-Ⅲ plays an important role in anticoagulant regulation in the human body, accounting for about 70%-80% of the total activity of the plasma anticoagulant system.It is involved in maintaining the homeostasis of the coagulation system and anticoagulant system in the body.In recent years, pediatricians have found that the AT-Ⅲ index has important clinical value in evaluating children's thrombosis, sepsis and nephrotic syndrome.This article mainly reviews the factors influencing the detection of antithrombin Ⅲ in children.
作者
胡静雯(综述)
秦晓松(审校)
Hu Jingwen;Qin Xiaosong(Medical Laboratory Department,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《国际儿科学杂志》
2019年第8期580-583,共4页
International Journal of Pediatrics
关键词
抗凝血酶Ⅲ
影响因素
质量控制
Antithrombin Ⅲ
Influencing factor
Quality control
