摘要
目的探讨复方玄驹胶囊与阿司匹林联合治疗对多囊卵巢综合征患者的临床效果以及用药安全性。方法回顾性分析2017年2月~2018年2月在某院治疗的72例多囊卵巢综合征患者的临床资料,依据用药方案的不同分为对照组(来曲唑,36例)与试验组(来曲唑+复方玄驹胶囊+阿司匹林,36例),比较两组血清性激素睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、用药安全性、排卵率以及妊娠率。结果治疗后,试验组T、LH、FSH以及E2水平均低于对照组,差异有统计学意义(P<0.05);两组均未出现明显不良反应,试验组排卵率与妊娠率均高于对照组,差异有统计学意义(P<0.05)。结论多囊卵巢综合征患者采用来曲唑、复方玄驹胶囊与阿司匹林联合治疗,可有效调节血清性激素水平,利于提高排卵率以及妊娠率,且用药安全性较高。
OBJECTIVE To investigate the effect and safety of compound Xuanju capsule combined with aspirin in treatment of polycystic ovarian syndrome( PCOS). METHODS The clinical data of 72 PCOS patients treated in the hospital from February 2017 to February 2018 were retrospectively analyzed. They were divided into control group( letrozole,36 cases) and experimental group( letrozole+compound Xuanju capsule + aspirin,36 cases) according to medication regimens. The serum sex hormones [testosterone( T),luteinising hormone( LH),follicle-stimulating hormone( FSH),estradiol( E2)],medication safety,ovulation rate,pregnancy rate were compared between the two groups. RESULTS After treatment,the levels of T,LH,FSH and E2 in experimental group were lower than those in control group( P<0.05). There were no obvious adverse reactions in the two groups,the ovulation rate and pregnancy rate in experimental group were higher than those in control group( P< 0.05). CONCLUSION Letrozole combined with compound Xuanju capsule and aspirin in treatment of PCOS can regulate the levels of serum sex hormones,increase the ovulation rate and pregnancy rate,and have higher medication safety.
作者
简冬群
袁涛
帅妹
刘莉英
陈春连
JIAN Dongqun;YUAN Tao;SHUAI Mei;LIU Liying;CHEN Chunlian(Ganzhou Maternal and Child Health Hospital,Pharmacy,Ganzhou ,Jiangxi 341000,China;Ganzhou Maternal and Child Health Hospital,Department of Reproductive Medicine ,Ganzhou ,Jiangxi 341000,China)
出处
《今日药学》
CAS
2019年第8期546-548,共3页
Pharmacy Today
基金
赣州市指导性科技计划(GZ2018ZSF340)
