期刊文献+

Cu-DNAzyme facilitates highly sensitive immunoassay

Cu-DNAzyme facilitates highly sensitive immunoassay
原文传递
导出
摘要 Fast and sensitive antigen detection is important in biomedical research and development. Despite, being invented 48 years ago, the enzyme-linked immunosorbent assay(ELISA) remains one of the most successful and widely employed bioanalytical techniques in research and clinical diagnostics due to its reliability and simplistic design. Recently, nanotechnology has offered efficient signal reporting. In spite of some improvements in these systems, there are typically increased material costs involved and the need for expensive equipment or complicated chemical processes, thus negating any possible benefits over ELISA. Herein, we communicate a simple Cu-DNAzyme system for signal transduction of a CuO nanoparticle-labeled immunoassay. The reported immunoassay amplifies signal generation similar to traditional ELISA and is fast, simple, cost-effective, and sensitive, holding promise for biomedical applications and point-of-care testing. Fast and sensitive antigen detection is important in biomedical research and development. Despite, being invented 48 years ago, the enzyme-linked immunosorbent assay(ELISA) remains one of the most successful and widely employed bioanalytical techniques in research and clinical diagnostics due to its reliability and simplistic design. Recently, nanotechnology has offered efficient signal reporting. In spite of some improvements in these systems, there are typically increased material costs involved and the need for expensive equipment or complicated chemical processes, thus negating any possible benefits over ELISA. Herein, we communicate a simple Cu-DNAzyme system for signal transduction of a CuO nanoparticle-labeled immunoassay. The reported immunoassay amplifies signal generation similar to traditional ELISA and is fast, simple, cost-effective, and sensitive, holding promise for biomedical applications and point-of-care testing.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第9期1652-1654,共3页 中国化学快报(英文版)
基金 supported by Beatrice Hunter Cancer Research Institute the ACOA AIF program CBU RISE program Nova Scotia Lands Innovacorp ESCF Phase Ⅰ grant the New Frontiers in Research Fund - Exploration Canada Foundation of Innovation John R. Evans Leaders Fund the Priority Academic Program Development of Jiangsu Higher Education Institutions NSERC Discovery Grants
关键词 Cu-DNAzyme IMMUNOASSAY ELISA CUO NANOPARTICLES Cu-DNAzyme Immunoassay ELISA CuO Nanoparticles
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部