摘要
观察高频热疗联合XELOX方案化疗治疗晚期结直肠癌的疗效、不良反应及其对患者血清血管内皮细胞生长因子(VEGF)水平的影响。方法79例经病理学证实的晚期结直肠癌患者分为治疗组和对照组,对照组44例患者给予单纯XELOX方案化疗,治疗组35例患者在XELOX方案化疗基础上加用高频热疗。结果治疗组有效率为80.00%(28/35),局部控制率为94.29%(33/35),均高于对照组的56.82%(25/44)、77.27%(34/44),差异均有统计学意义(P均<0.05)。2组骨髓抑制、胃肠道反应、周围神经毒性发生率比较差异均无统计学意义(P均>0.05)。2组治疗后血清VEGF水平均低于治疗前,差异均有统计学意义(P均<0.05)。治疗后,治疗组血清VEGF水平低于对照组,差异有统计学意义(P<0.05)。结论高频热疗联合XELOX方案治疗晚期结直肠癌疗效较好,不良反应未见明显增加,且血清VEGF明显下降,值得临床推广。
Objective To observe the efficacy and adverse reactions of thermotherapy combined with XELOX chemotherapy in the treatment of advanced colorectal cancer and the effect on the serum vascular endothelial growth factor (VEGF) levels. Methods Seventy-nine patients with advanced colorectal cancer were divided into two groups. Forty-four patients in the control group received only XELOX chemotherapy, 35 patients in the treatment group received thermotherapy combined with XELOX chemotherapy. Results The response rate and the disease control rate were 80.00%(28/35)and 94.29%(33/35) in the treatment group, and were 56.82%(25/44)and 77.27%(34/44)in the control group ( P <0.05). There was no difference in the myelosuppression, gastrointestinal toxicity and peripheral nerve abnormality between the treatment group and the control group ( P >0.05). In the two groups, the serum VEGF level after treatment were lower than those before treatment ( P <0.05).After treatment, the serum VEGF level in the treatment group were lower than those in the control group( P <0.05). Conclusion Thermotherapy combined with XELOX chemotherapy is safe and effective for patients with advanced colorectal cancer, and this regimen can reduce the VEGF levels.
作者
温林春
朱信强
陆锡燕
尤传文
WEN Linchun;ZHU Xinqiang;LU Xiyan;YOU Chuanwen(Department of Oncology,Suqian Hospital Affiliated to Xuzhou Medical University,Suqian 223800,China;Department of General Surgery,Suqian Hospital Affiliated to Xuzhou Medical University,Suqian 223800,China)
出处
《肿瘤基础与临床》
2019年第3期205-207,共3页
journal of basic and clinical oncology
基金
宿迁市科技创新计划项目(S201715)
关键词
结直肠癌
高频热疗
化疗
血管内皮生长因子
colorectal cancer
hyperthermia
chemotherapy
vascular endothelial growth factor
