摘要
目的探讨DRD2 TaqIA不同基因型海洛因成瘾者抑制控制网络的差异。材料与方法收集57例海洛因成瘾者,根据DRD2 TaqIA基因类型分为A+型组(35例)与A-型组(22例),匹配46名健康者。首先评估三组冲动性量表,然后以右侧额下回为种子点作全脑功能连接,统计分析海洛因组与健康对照组及A+型组与A-型组脑网络差异。结果海洛因组冲动总分、行为冲动及无计划冲动均显著高于正常组,而A+型组与A-型组差异无统计学意义;与正常组相比,海洛因成瘾组右侧额下回与双侧后扣带、楔前叶、舌回及距状回功能连接增强,与双侧顶叶功能连接降低;与A-型组相比,A+型组右侧额下回与小脑功能连接增强,与双侧前扣带、内侧前额叶及左侧岛叶功能连接降低。结论海洛因成瘾者心理冲动性较高且抑制控制网络存在异常;与A-基因型相比,A+基因型海洛因成瘾者抑制控制能力更差,可能更易觅药或复吸。
Objective: To investigate the differences in inhibition control networks between different genotype heroin addicts of DRD2 TaqIA. Materials and Methods: A total of 57 heroin addicts were recruited. The DRD2 TaqIA gene type was divided into A+ group and A-type group, matching 46 healthy individuals. Firstly, three groups of impulsive scales were evaluated, and then the right inferior frontal gyrus was used as the whole brain functional connection. Results: The differences brain network were statistically analyzed between the heroin group and the healthy control group, the A+ group and the A-type group. The total scores of impulses, behavioral impulses and unplanned impulses in heroin group were significantly higher than those in normal group, but there was no significant difference between type A+ group and A- type group. Compared with the normal group, the functional connections between the right inferior frontal gyrus and bilateral posterior cingulate, anterior cuneiform, lingual gyrus and talus gyrus were enhanced, and bilateral parietal lobe were decreased in heroin addiction group. Compared with the A-type group, the functional connections between the right inferior frontal gyrus and cerebellum were enhanced, and bilateral anterior cingulate, medial prefrontal and left insular lobes were decreased in A+ type group. Conclusions: Heroin addicts have higher psychological impulsivity and abnormal control network;compared with A-genotype, A+ genotype heroin addicts have less inhibition and control ability, and may be more likely to take drugs or relapse.
作者
李小怀
朱国平
蔡关科
敬甲兵
王帆
刘为
时宏
胡风
王玮
LI Xiaohuai;ZHU Guoping;CAI Guanke;JING Jiabing;WANG Fan;LIU Wei;SHI Hong;HU Feng;WANG Wei(Department of Nuclear Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;Department of Radiology, Fourth Affiliated Hospital of Medical College of Zhejiang University, Yiwu 322000, China;Department of Radiology, First People's Hospital of Qingyang City, Gansu Province, Qingyang 745000, China)
出处
《磁共振成像》
CAS
2019年第9期661-666,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:8147648)~~
