摘要
目的研究4种血清肿瘤标记物对结直肠癌术后转移和复发的判定价值。方法该次研究方便选择该院住院部2017年1月-2018年12月收治的结直肠癌患者138例,采用ELISA分析法对患者的CEA、CA19-9、CA242和CA724血清肿瘤标记物进行检测,比较单项检测和联合检测的意义,并对患者进行术后2年随访。结果在对结直肠癌患者的检测结果中发现,CEA特异度与灵敏度最高,分别为78.4%和65.2%,其次为CA242,分别为71.6%、59.7%。采用平行法进行检查,可将灵敏度提高到89.7%,采用系列检测,可将特异度提高到91.5%,患者经结直肠癌根治术治疗后的第3周起,体内各项血清肿瘤标记物均明显降低,术后发生远处转移共59例,占比42.7%,远处转移(+)组患者相比远处转移(-)组患者的CEA、CA19-9、CA242、CA724值均明显提升,差异有统计学意义(标记物t=9.24、8.19、12.04、9.45;生物学行为t=9.76、11.82、9.94、11.28,P<0.05)。结论通过监测血清CEA、CA19-9、CA242和CA724值,能在一定程度上评价结直肠癌的诊断、手术效果及后期转移,4项指标联合检测能有效提高检测特异性与敏感度,对患者的长期生存率具有重要价值。
Objective To study the value of four serum tumor markers in the metastasis and recurrence of colorectal cancer.Methods In this study,138 patients with colorectal cancer admitted to our hospital from January 2017 to December 2018 were convenient selected and enrolled.The serum tumor markers of CEA,CA19-9,CA242 and CA724 were detected by ELISA.The significance of single and combined tests was compared and patients were followed up for 2 years.Results In the test results of colorectal cancer patients,CEA specificity and sensitivity were the highest,78.4% and 65.2%,respectively,followed by CA242,71.6%,59.7%.Using the parallel method to check,the sensitivity can be increased to 89.7%,using a series of tests,the specificity can be increased to 91.5%,the patient's serum tumor markers in the third week after the treatment of colorectal cancer radical surgery significantly reduced,a total of 59 cases of distant metastasis occurred after surgery,accounting for 42.7%,the distant metastasis (+) group compared with the distant metastasis (-) group of CEA,CA19-9,CA242,CA724 values were significantly improved.The difference was statistically significant (markers t=9.24、8.19、12.04、9.45;biological behavior t=9.76、11.82、9.94、11.28,P<0.05).Conclusion By monitoring the serum CEA,CA19-9,CA242 and CA724 values,the diagnosis,surgical effect and metastasis of colorectal cancer can be evaluated to some extent.The combined detection of four indicators can effectively improve the detection specificity and sensitivity.The long-term survival rate has important value.
作者
樊成红
樊成丽
FAN Cheng-hong;FAN Cheng-li(Department of Laboratory,Fenyang College,Shanxi Medical University,Fenyang,Shanxi Province,032200 China;Operating Room of Fenyang People's Hospital,Fenyang,Shanxi Province,032200 China)
出处
《中外医疗》
2019年第23期192-194,共3页
China & Foreign Medical Treatment
关键词
血清肿瘤标记物
结直肠癌
转移
复发
监测
Serum tumor markers
Colorectal cancer
Metastasis
Recurrence
Monitoring
