摘要
目的 探究甲状腺功能亢进性心脏病(HHD)患者血清肌钙蛋白Ⅰ(cTnI)、氨基末端脑钠肽前体(NT-proBNP)、肌酸激酶(CK)、肌酸激酶同工酶MB(CK-MB)水平及临床意义。方法选取2013年2月至2018年10月本院收治的单纯甲亢及HHD患者各74例,分别作为甲亢组、HHD组;选取同期体检健康者74例为对照组。观察3组血清cTnI、NT-proBNP、CK、CK-MB及心功能指标(LVEF、LVESD、LVEDD)水平;比较HHD不同心功能分级患者血清cTnI、NT-proBNP、CK、CK-MB水平;分析血清指标与心功能指标相关性。结果 HHD组血清cTnI、NT-proBNP、CK、CK-MB水平分别为(0.59±0.13)μg/L、(1765.28±153.69)pg/ml、(316.25±54.89)U/L、(67.42±9.76)U/L;甲亢组血清cTnI、NT-proBNP、CK、CK-MB水平分别为(0.30±0.08)μg/L、(549.85±72.13)pg/ml、(199.41±23.45)U/L、(22.36±4.08)U/L;对照组血清cTnI、NT-proBNP、CK、CK-MB水平分别为(0.12±0.04)μg/L、(53.67±8.04)pg/ml、(42.16±7.38)U/L、(6.51±1.13)U/L。血清cTnI、NTproBNP、CK、CK-MB水平HHD组>甲亢组>对照组(均P<0.05);随HHD患者心功能分级增加,血清cTnI、NT-proBNP、CK、CK-MB水平升高,Ⅳ级>Ⅲ级>Ⅱ级>I级,差异有统计学意义(均P<0.05)。LVEF水平HHD组<甲亢组<对照组,LVESD、LVEDD水平HHD组>甲亢组>对照组(均P<0.05)。Pearson相关分析显示,cTnI、NT-proBNP、CK、CK-MB与LVEF均呈负相关(均P<0.05),与LVESD、LVEDD均呈正相关(均P<0.05)。结论 血清cTnI、NT-proBNP、CK、CK-MB在HHD患者中呈相对高表达,可反映心功能受损程度,这对HHD临床诊断及病情评估具有重要辅助价值。
Objective To investigate the levels of serum cardiac troponin I (cTnI), N-terminal probrain natriuretic peptide (NT-proBNP), creatine kinase (CK), and creatine kinase MB(CK-MB) in patients with hyperthyroidism heart disease (HHD) and the significance. Methods From February, 2013 to October, 2018, 74 patients with hyperthyroidism and 74 with HHD were enrolled in the hospital and set as a hyperthyroidism group and a HHD group. 74 healthy examinees were selected as a control group. The serum levels of cTnI, NT-proBNP, CK, and CK-MB and cardiac function indicators (LVEF, LVESD, and LVEDD) were observed. The serum levels of cTnI, NT-proBNP, CK, and CK-MB were compared between the patients with different HMD scores. The correlation between serum indicators and cardiac function indicators was analyzed. Results The serum levels of cTnI, NT-proBNP, CK, and CK-MB were (0.59±0.13)μg/L,(1 765.28±153.69) pg/Ml,(316.25±54.89) U/L, and (67.42±9.76) U/L in the HHD group, were (0.30±0.08)μg/L,(549.85±72.13) pg/ml,(199.41±23.45) U/L, and (22.36±4.08) U/L in the hyperthyroidism group, and were (0.12±0.04)μg/L,(53.67±8.04) pg/ml,(42.16±7.38) U/L, and (6.51±1.13) U/L in the control group. The serum levels of cTnI, NT-proBNP, CK, and CK-MB in the HHD group > those in the hyperthyroidism group > those in the control group (all P < 0.05). The serum levels of cTnI, NT-proBNP, CK, and CK-MB increased with the grade of heart function in patients with HHD: grade Ⅳ>Ⅲ>Ⅱ> I, with statistical differences (all P < 0.05). The LVEF in the HHD group < that in the hyperthyroidism group < that in the control group, and the LVESD and LVEDD in the HHD group > those in the hyperthyroidism group > those in the control group (all P < 0.05). Pearson correlation analysis showed that cTnI, NT-proBNP, CK, and CK-MB negatively correlated LVEF (P < 0.05), and positively with LVESD and LVEDD (all P < 0.05). Conclusion Serum cTnI, NT-proBNP, CK, and CK-MB have relatively high expressions in HHD patients, which may reflect the degree of cardiac function impairment and have important auxiliary value for the clinical diagnosis and disease assessment of HHD.
作者
宋丽
许士达
邢海燕
Song Li;Xu Shida;Xing Haiyan(Dezhou People's Hospital,Dezhou 253014,China)
出处
《国际医药卫生导报》
2019年第17期2901-2904,共4页
International Medicine and Health Guidance News
