摘要
甾体药物已经成为仅次于抗生素的第二大类药物。在甾体药物或其中间体的合成路线中,微生物转化是不可或缺的关键环节。本文中,笔者从微生物转化、甾醇侧链降解反应、强化生物转化效率的策略等方面对甾体激素药物近几年的研究现状进行综述。
Steroids have become the second largest class of drugs after antibiotics.Microbial transformation is an indispensable key to synthesize steroids or intermediates.We review the research status of steroid hormone drugs in recent years from the aspects of microbial transformation,side chain degradation reaction and strategies to enhance biotransformation efficiency.
作者
徐慧静
刘萍
崔立迁
牛建娜
XU Huijing;LIU Ping;CUI Liqian;NIU Jianna(Tianjin Food Safety Detection Technology Research Institute,Tianjin 300308,China;Tianjin Product Quality Inspection Technology Research Institute,Tianjin 300384,China)
出处
《生物加工过程》
CAS
2019年第5期542-550,共9页
Chinese Journal of Bioprocess Engineering
关键词
甾体激素药物
生物转化方法
生物转化体系
steroid hormone drugs
biotransformation method
bioconversion system
