摘要
目的探讨纳洛酮联合脑苷肌肽复方注射液在重症颅脑损伤围术期的应用效果。方法将79例重症颅脑损伤患者随机分为单用组(37例,纳洛酮治疗)和联用组(42例,纳洛酮+脑苷肌肽复方注射液治疗)。比较两组的治疗效果。结果术后即刻及术后14 d,两组血清GFAP及NSE水平均低于术前(P<0.05)。术后14 d,两组血清GFAP及NSE水平均低于术后即刻(P<0.05)。术后即刻及术后14 d,联用组的血清GFAP及NSE水平均低于单用组(P<0.05)。联用组治疗总有效率显著高于单用组(P<0.05)。结论重症颅脑损伤围术期使用纳洛酮联合脑苷肌肽复方注射液可改善患者的神经功能,提升治疗效果。
Objective To explore the application effect of naloxone combined with cerebroside carnosine compound injection on perioperative period of severe craniocerebral injury. Methods A total of 79 patients with severe craniocerebral injury were randomly divided into single-use group(37 cases, treated with naloxone) and combination group(42 cases,treated with naloxone+cerebroside carnosine compound injection). The therapeutic effects were compared between the two groups. Results Immediately after surgery and at 14 days after surgery, the levels of serum GFAP and NSE of the two groups were lower than those before surgery(P<0.05). At 14 days after surgery, the levels of serum GFAP and NSE of the two group were lower than those immediately after surgery(P<0.05). Immediately after surgery and 14 days after surgery,the levels of serum GFAP and NSE of the combination group were lower than those of the single-use group(P<0.05). The total effective rate of treatment in the combination group was higher than that in the single-use group(P<0.05). Conclusion Naloxone combined with cerebroside carnosine compound injection on perioperative period of severe craniocerebral injury can improve neurological function of patients and therapeutic effect.
作者
张晓庆
ZHANG Xiao-qing(Xi'an Kunlun Hospital,Xi'an 710043,China)
出处
《临床医学研究与实践》
2019年第27期42-43,共2页
Clinical Research and Practice
关键词
纳洛酮
脑苷肌肽复方注射液
重症颅脑损伤
naloxone
cerebroside carnosine compound injection
severe craniocerebral injury
