摘要
结合近10年国内外中药逆转肝癌多药耐药的相关研究,就中药在抑制膜转运蛋白、抑制多药耐药性(MDR)基因、抑制抗细胞凋亡途径、逆转酶介导的MDR、改善肿瘤细胞微环境等方面的肝癌多药耐药逆转作用作概述,并总结研究中存在的问题及发展方向,为临床治疗方案提供新思路。
Considering relevant studies on reversal of multidrug resistance in liver cancer in recent 10 years both at home and abroad, this paper summarizes the reversal effect of traditional Chinese medicine in liver cancer in inhibiting membrane transporter, inhibiting multidrug resistance(MDR) genes, inhibiting the anti-apoptotic pathway, reversing enzyme-mediated MDR and improving the microenvironment of tumor cells, and also summarizes the existing problems in and the direction of research, so as to provide new ideas for clinical treatment.
作者
余云霞
夏嘉文
熊友香
YU Yunxia;XIA Jiawen;XIONG Youxiang(College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 311400, Zhejiang, China)
出处
《上海中医药杂志》
2019年第8期92-97,共6页
Shanghai Journal of Traditional Chinese Medicine
基金
浙江省中医药科技计划项目(2015ZB038)
关键词
中药
肝癌
多药耐药
逆转
机制
综述
traditional Chinese medicine
liver cancer
multidrug resistance
reversal
mechanism
review
