摘要
目的研究并分析妊娠期糖尿病患者胰岛素抵抗程度与血清25-羟维生素D水平之间的相关性。方法收集2017年10月-2019年2月间于南充市中心医院妇产科确诊为妊娠期糖尿病(GDM)的90例患者以及同期产检的90例健康孕妇作为研究对象,其中GDM患者为观察组,健康孕妇为对照组。检测并记录两组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、空腹胰岛素(FINS)、空腹血糖(FBG)等一般糖脂代谢指标以及血清25-羟维生素D(25-OH-VD)、稳态模型胰岛素抵抗指数(HOMA-IR)和β细胞功能指数(HOMA-β),并利用t检验、Pearson相关性分析和Logistic回归分析等方法进行统计学分析。结果两组患者TC、TG、LDL-C、HDL-C等指标比较,差异无统计学意义(P>0.05);但与对照组相比,观察组患者HOMA-IR、FBG、FINS均显著升高,而25-OH-VD、HOMA-β均显著降低,差异具有统计学意义(P<0.05);Pearson相关性分析显示,25-OH-VD与FBG、FINS、HOMA-IR呈负相关,与HOMA-β呈正相关;Logistic回归分析显示,25-OH-VD是GDM发病的独立危险因素。结论维生素D缺乏或不足,将在一定程度上增加妊娠期妇女GDM的患病风险,与GDM患者的胰岛素抵抗存在紧密联系。
Objective To study and analyze the correlation between insulin resistance and serum 25-hydroxy vitamin D(25-OH-VD) levels in patients with gestational diabetes mellitus(GDM). Methods A total of 90 cases of gestational diabetes mellitus diagnosed in the hospital from October 2017 to February 2019 were selected as observation group, while 90 cases of healthy pregnant women during the same period of labor examination were randomly selected as control group. Two groups of patients were measured and recorded the general glucolipid metabolic index such as TC, TG, LDL-c, HDL-c, FINS, and FBG, serum 25-OH-VD, the steady-state model of insulin resistance index(HOMA-IR) and beta cell function index(HOMA-β). Results There were no statistically significant differences in TC, TG, LDL-c, HDL-c and other indicators between the two groups(P>0.05). Compared with the control group, FBG, FINS, and HOMA-IR were all significantly higher, while 25-OH-VD and HOMA-β were significantly lower in the observation group(P<0.05). Pearson correlation analysis showed that 25-OH-VD was negatively correlated with FINS, FBG and HOMA-IR, while it was positively correlated with HOMA-β. Logistic regression analysis showed that 25-OH-VD was an independent risk factor for GDM. Conclusion Vitamin D deficiency or insufficiency may increase the risk of GDM in pregnant women to some extent, which is closely related to insulin resistance in GDM patients.
作者
张利平
陈国栋
ZHANG Liping;CHEN Guodong(Department of Obstetrics and Gynecology, Nanchong Central Hospital of Sichuan Provice, Nanchong Sicuan 645000,China)
出处
《新疆医科大学学报》
CAS
2019年第10期1310-1314,共5页
Journal of Xinjiang Medical University
基金
国家横向回顾性研究项目(W2016CWSC02)
关键词
妊娠期糖尿病
25-羟维生素D
胰岛素抵抗
相关性
Gestational diabetes mellitus(GDM)
25-hydroxy vitamin D(25-OH-VD)
insulin resistance(IR)
correlation
the second trimester of pregnancy
