摘要
目的探讨2种以丹参为主要成分的常用中药制剂治疗心肌缺血的效果。方法选取104例冠心病心肌缺血患者随机分为治疗A组和治疗B组,各52例。在常规西医对症治疗基础上,治疗A组给予丹参注射液治疗,治疗B组给予丹参酮ⅡA磺酸钠注射液治疗,均持续治疗4周。观察2组治疗前后ST段下移幅度、缺血性发作次数及时间变化,并比较2组心电图变化情况、临床疗效以及安全性。结果治疗后,2组ST段下移幅度、缺血性发作次数、缺血性发作时间均较治疗前显著下降(P<0.05),且治疗A组较治疗B组下降更为显著(P<0.05);治疗A组心电图总有效率90.38%、临床总有效率92.31%,高于治疗B组的75.00%、76.92%,差异有统计学意义(P<0.05);治疗A组、B组的不良反应发生率分别为9.62%、7.69%,差异无统计学意义(P>0.05)。结论以丹参为主要成分的2种中药制剂对于改善冠心病心肌缺血均有积极作用,而丹参注射液的疗效优于丹参酮ⅡA磺酸钠注射液。
Objective To explore the effect of two traditional Chinese medicine preparations with salvia miltiorrhiza as the main ingredient in the treatment of myocardial ischemia.Methods A total of 104 coronary heart disease patients with myocardial ischemia were randomly divided into treatment A group and treatment B group,with 52 cases in each group.The patients of two groups were all given symptomatic treatment of conventional western medicine,group A was additionally treated with salvia miltiorrhiza injection while group B was additionally treated with sodium tanshinoneⅡA sulfonate injection,the treatment of two groups lasted for 4 weeks.The degree of ST segment decrease,changes of ischemic attack times and duration before and after treatment were observed,and the changes of electrocardiogram,clinical efficacy and safety of the two groups were compared.Results After treatment,the range of ST segment decrease,frequency and duration of ischemic attacks decreased significantly in both groups(P<0.05).Compared with group B,and group A decreased more significantly(P<0.05).The total effective rate of electrocardiogram,and clinical total effective rate in group A were 90.38%,92.31%,respectively,which were higher than 75.00%,76.92%,respectively,in group B(P<0.05).The incidence of adverse reactions of group A and group B were 9.62%and 7.69%,respectively,but there was no significant difference between the two groups(P>0.05).Conclusion Salvia miltiorrhiza injection and sodium tanshinoneⅡA sulfonate injection play an important role in improving myocardial ischemia of coronary heart disease,but the former has better efficacy than the latter one.
作者
严卫
刘晨霞
YAN Wei;LIU Chenxia(Department of Pharmacy,Shangluo Hospital of Traditional Chinese Medicine, Shangluo,Shaanxi,726000;Pharmacy of Traditional Chinese Medicine, Yulin Mental Health Center,Yulin,Shaanxi,719000)
出处
《实用临床医药杂志》
CAS
2019年第18期112-115,共4页
Journal of Clinical Medicine in Practice
关键词
心肌缺血
丹参注射液
丹参酮ⅡA磺酸钠注射液
心电图
临床疗效
myocardial ischemia
salvia miltiorrhiza injection
sodium tanshinoneⅡA sulfonate injection
electrocardiogram
clinical efficacy
