摘要
感染性疾病(ID)是病原微生物侵入机体引起炎症或器官功能障碍性疾病。其致病机制复杂,尚未完全阐明。颗粒蛋白前体(PGRN)是一种多功能分泌性糖蛋白,在胚胎发育、肿瘤形成、炎性反应、免疫应答等方面均发挥重要作用。最近有多个研究表明,PGRN与多种ID密切相关。该文综述了PGRN在各种微生物感染导致的ID中的免疫调节最新研究进展。
Infectious diseases(ID)are diseases caused by pathogenic microorganisms invading the body and causing inflammation or organ dysfunction.Its pathogenesis is complex and has not been fully elucidated.Progranulin(PGRN)is a multifunctional secretory glycoprotein that plays an important role in embryonic development,tumor formation,inflammatory response and immune response.Several recent studies have shown that PGRN is closely related to various ID.This paper reviews the latest research progress of immune regulation of PGRN in ID caused by various microbial infections.
作者
饶露蓓
余小燕
宋志新
陈大鹏
尹一兵
RAO Lubei;YU Xiaoyan;SONG Zhixin;CHEN Dapeng;YIN Yibing(Department of Clinical Laboratory,Children′s Hospital Affiliated to Chongqing Medical University,Chongqing 400014,China)
出处
《国际检验医学杂志》
CAS
2019年第19期2393-2397,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金资助项目(31640025、81801956)
