摘要
口腔种植技术是牙列缺损及牙列缺失的重要修复方式之一,可以良好恢复牙列的形态、功能及整体美观。但种植体周围骨整合的缺乏、周围骨吸收及相关感染等问题均可能导致植入物松动、治疗失败,限制了种植治疗的进一步应用与推广。近年来,随着纳米技术快速发展,其在生物医学领域中已有广泛应用,学者们通过表面涂层、图案化等多种方式对种植体进行纳米层面的表面改性和(或)本体改性,以提高种植体表面积及表面活性,促进骨整合相关蛋白、细胞的黏附、定植,改善种植体的机械性能、理化性能及生物学性能。
Implant prothesis is now a frequently used treatment in prosthodontics,which can restore the morphology,function and aesthetic. However,there are crucial issues that result in failure sometimes: implant-related infection,the lack of implant-bone integration and bone resorption,which limit the further application and promotion of the therapy. Nanotechnology,with its rapid development,has been widely applied in biomedicine,and scholars modify the surface and/or bulk of implants by means of surface coating and patterning,in order to improve the surface area and surface activity of implants,promote the adhesion and colonization of osteointegration-related proteins and cells,and improve the mechanical,physical,chemical and biological properties of implants.
作者
杨雨青
曹志炜
巫佩瑶
周陶
解亮
YANG Yuqing;CAO Zhiwei;WU Peiyao;ZHOU Tao;XIE Liang(West China College of Stomatology,State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases,Sichuan University,Chengdu 610041,China)
出处
《医学综述》
2019年第18期3627-3633,3640,共8页
Medical Recapitulate
基金
国家自然科学基金青年基金(81600842)
关键词
口腔种植体
纳米结构
表面改性
成骨特性
抗菌性
Dental implants
Nano-structure
Surface modification
Osteointegration
Antibacterial activity
