摘要
目的:分析血常规指标外周血白细胞(WBC)、中性粒细胞(NEUT)、淋巴细胞数(LYM)、中性粒细胞/淋巴细胞比值(NLR)、血小板计数(PLT)、血小板/淋巴细胞比值(PLR)和血小板平均体积(MPV)对不同听力曲线类型突发性耳聋(SHL)疗效的影响。方法:将92例SHL患者与87例对照组比较。并将SHL患者分型,比较分析治疗有效组与无效组之间血常规指标。结果:①SHL组WBC、NEUT、PLT、NLR和PLR的数值高于对照组(P<0.01),LYM低于对照组(P<0.01);②不同听力曲线类型间SHL疗效差异有统计学意义(P<0.01),低频下降型治疗有效组的WBC、NEUT和NLR低于无效组(P<0.05);③多因素非条件Logistic回归分析显示,SHL患者发病时WBC、NEUT升高有利于实现疗效(OR=14.757,95%CI:2.498~87.169和OR=6.960,95%CI:1.080~44.868),而PLT和PLR升高则是疗效的消极因素(OR=0.119,95%CI:0.018~0.775和OR=1.016,95%CI:1.002~1.029)。结论:血常规中炎性反应指标与SHL的发病存在相关性,患者发病时血常规中WBC、NEUT、PLT和PLR对预后有一定预测作用。
Objective: To analyze the indexes of peripheral white blood leukocyte (WBC),neutrophil (NEUT),lymphocyte count (LYM),neutrophil/lymphocyte ratio (NLR),platelet count (PLT),platelet/lymphocyte ratio (PLR) and platelet mean volume (MPV) on the therapeutic efficacy of sudden hearing loss(SHL) with different hearing curve types. Methods :Ninety-two patients with SHL(SHL group) and 87 controls(control group) were included,and compared concerning the results of blood routine tests between patients with therapeutic effects and failure of therapy. Results :①Patients in SHL group had higher levels of WBC,NEUT,PLT,NLR and P LR,yet lower LYM than those in control group (both P <0.01);②There were statistical differences by efficacies in SHL with different types of hearing curve ( P< 0.01),and WBC,NEUT and NLR were significantly lower in SHL of low-frequency decreasing type with therapeutic efficacy than in patients with therapy failure( P< 0.05);③Multivariate unconditional Logistic regression analysis showed that increased WBC and NEUT in SHL patients at disease attack were contributable to therapeutic effect( OR =14.757,95% CI :2.498-87.169;OR =6.960,95% CI :1.080-44.868),whereas elevated PLT and PLR were negative factors for the therapeutic outcomes( OR =0.119,95% CI :0.018-0.775;OR = 1.016 ,95% CI :1.002-1.029). Conclusion :Inflammatory reaction indices measured in blood routine tests are correlated with the occurrence of SHL,and WBC,NEUT,PLT and PLR in blood routine can be predictors for the prognosis of SHL.
作者
伍丽娟
马俊
刘少峰
WU Lijuan;MA Jun;LIU Shaofeng(Department of Otolaryngology-Head and Neck Surgery,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)
出处
《皖南医学院学报》
CAS
2019年第5期458-461,共4页
Journal of Wannan Medical College
基金
弋矶山医院2018年三新项目(Y1807)
关键词
血常规指标
突发性耳聋
影响分析
blood routine indexes
sudden hearing loss
impact analysis
