摘要
目的探讨帕罗西汀对外周血细胞因子白细胞介素-1β和和白细胞介素-6影响。方法选择2017 年5月-2018年5月台州市黄岩区第三人民医院精神科就诊的抑郁症患者60例,按随机数字法分为对照组和观察组各30例。对照组给予心理干预,观察组在对照组基础上给予盐酸帕罗西汀口服,比较2组治疗后汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表( HAMD)评分及白细胞介素-1β(IL- 1β)和白细胞介素-6(IL-6)水平。结果治疗后 HAMA和HAMD评分比较,观察组显著低于对照组(t值分别为6.46、8. 28,P <0.01);治疗后外周血IL-1β和IL-6水平比较,观察组显著低于对照组(t值分别为5.67 3.52,P<0.01)。结论帕罗西汀可显著降低抑郁症外周血IL-1β和IL- 6水平。
Objective To investigate the influence of Pa Rossi Dean on cytokines interleukin- 1 beta and interleukin-6 in peripheral blood. Methods Sixty patients with depression in Psychiatric Department of the Third People's Hospital of Huangyan Distriet in Taizhou were selected from May 2017 to May 2018,who were randomly divided into control group and observation group, with 30 cases in each group. Psychological intervention was given in the control group,while oral paroxetine hydrochlo- ride was given in the observation group on the basis of the control group. Then the score of Hamilton Anxiety Scale ( HAMA) and Hamilton Depression Scale ( HAMD),the levels of interleukin - 1β(IL- 1 beta) and interleukin -6 (IL-6) were compared between the two groups after treatment. Results After treatment, the scores of HAMA and HAMD were significantly lower in the observation group than that in the control group (t=6.46, t=8.28, P<0.01). The levels of interleukin- 1β(IL-1 beta) and interleukin-6 (IL- 6) in peripheral blood were signifcantly lower in the observation group than that in the control group (t=5.67, t=3.52, P <0.01). Conclusion Pa Rossi Dean can significantly reduce the levels of interleukin-1β and interleukin - 6 in peripheral blood in patients with depression.
作者
吴新君
罗忠
张君青
陈文泽
WU Xin-jun;LUO Zhong;ZHANG Jun-qing;CHEN Wen-ze(Department of Psychiatric, the Third People’ s Hospital of Huangyun District in Taizhou, Taizhou, Zhejiang 318020, China)
出处
《中国卫生检验杂志》
CAS
2019年第19期2351-2353,共3页
Chinese Journal of Health Laboratory Technology
基金
台州市科技局资助项目(121ky11-26)
