摘要
目的探讨2型糖尿病(T2DM)患者血尿酸(UA)水平与肾功能的相关性。方法选取2018年1月至2019年2月我院收治的141例T2DM患者作为研究对象。根据估测肾小球滤过率(eGFR)将患者分为eGFR<60组[76例,eGFR<60 mL/(min·1.73 m^2)]和eGFR≥60组[65例,eGFR≥60 mL/(min·1.73 m^2)]。根据UA水平将患者分为UA1组(40例,UA<255.76 μmol/L)、UA2组(50例,UA 255.76~333.01 μmol/L)、UA3组(51例,UA> 333.01 μmol/L)。分析不同eGFR及不同UA水平患者的临床资料及相关性。结果 eGFR<60组患者的年龄、收缩压、肌酐(Scr)、尿素氮(BUN)、UA水平、尿白蛋白/肌酐比值(ACR)及lnACR均明显高于eGFR≥60组(P<0.05)。UA3组患者的Scr、BUN和UA水平均显著高于UA1及UA2组(P<0.05)。Pearson相关分析结果显示,UA水平与eGFR呈负相关(r=-0.44,P<0.05),ACR≥30 mg/g的患者UA水平与lnACR呈正相关(r=0.36,P<0.05)。多因素Logistic回归分析显示,UA3组UA水平是发生eGFR<60 mL/(min·1.73 m^2)的独立危险因素(OR=1.97,P<0.05),UA2组UA水平为其保护因素(OR=0.71,P<0.05)。结论 T2DM患者UA水平升高可引起eGFR下降和ACR升高,是影响肾功能的危险因素,因此UA可作为预测糖尿病肾脏疾病的有效指标。
Objective To explore the correlation between blood uric acid (UA) level and renal function in patients with type 2 diabetes mellitus (T2DM). Methods A total of 141 patients with T2DM admitted in our hospital from January 2018 to February 2019 were selected as the study objects and divided into eGFR<60 group [76 cases, eGFR<60 mL/(min·1.73 m^2)] and eGFR≥60 group [65 cases, eGFR≥60 mL/(min·1.73 m^2)] according to eGFR. The patients were divided into UA1 group (40 cases, UA<255.76 μmol/L), UA2 group (50 cases, UA 255.76-333.01 μmol/L) and UA3 group (51 cases, UA>333.01 μmol/L) according to UA levels. The clinical data and correlation between different eGFR and different UA levels in patients were analyzed. Results The age, systolic blood pressure, serum creatinine (Scr), urea nitrogen (BUN), UA levels, urinary albumin/creatinine ratio (ACR) and lnACR in the eGFR<60 group were significantly higher than those in the eGFR≥60 group (P<0.05). The levels of Scr, BUN and UA in the UA3 group were significantly higher than those in the UA1 and the UA2 group (P<0.05). Pearson correlation analysis showed that the UA level was negatively correlated with eGFR (r=-0.44, P<0.05), and the UA level was positively correlated with lnACR in patients with ACR≥30 mg/g (r=0.36, P<0.05). The multivariate Logistic regression analysis showed that the UA level in the UA3 group was an independent risk factor of eGFR<60 mL/(min·1.73 m^2)(OR=1.97, P<0.05), and the UA level in the UA2 group was a protective factor of which(OR=0.71, P<0.05). Conclusion For T2DM patients, elevating UA level which causing eGFR decrease and ACR increase can be identified as a risk factor for renal function. Thus, UA level can be as an effective prediction indicator of diabetic kidney disease.
作者
欧海青
戴尊收
OU Hai-qing;DAI Zun-shou(Nephrotic Rheumatology Department, Affiliated Hospital of Shandong Medical College, Linyi 276000, China)
出处
《临床医学研究与实践》
2019年第29期126-127,151,共3页
Clinical Research and Practice
关键词
糖尿病肾脏疾病
血尿酸
尿白蛋白/肌酐比值
diabetic kidney disease
blood uric acid
urine albumin/creatinine ratio
