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血清PDGF、Ang-2与冠状动脉粥样硬化斑块性质的关系 被引量:8

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摘要 目的探讨血小板源性生长因子(PDGF)、血管生成素2(Ang-2)与冠状动脉粥样硬化斑块性质的相关性。方法选取在我院治疗的冠心病患者110例,其中急性冠状动脉综合征(ACS)患者45例(ACS组),稳定型心绞痛(SAP)患者65例(SAP组),同时选取健康志愿者60例作为对照组,检测各组血清PDGF和Ang-2水平,同时采用血管内超声(IVUS)和冠状动脉造影检测ACS组和SAP组。结果 SAP组PDGF和Ang-2分别为(3. 67±0. 56) ng/L和(354. 22±30. 20) pg/m L,明显高于ACS组和对照组(P <0. 05);SAP组偏心指数和Gensini积分分别为(0. 63±0. 21)和(46. 59±7. 22)分,明显高于ACS组(P <0. 05);SAP组以稳定斑块、混合斑块为主,ACS组以易损斑块为主比较差异有统计学意义(P <0. 05);PDGF、Ang-2与偏心指数呈正相关(r=0. 30和0. 30,P <0. 05);PDGF、Ang-2与Gensini积分呈正相关(r=0. 51和0. 51,P <0. 05)。结论血清PDGF、Ang-2水平与冠状动脉粥样硬化斑块性质以及冠状动脉病变程度有一定相关性。
出处 《心脑血管病防治》 2019年第5期427-428,431,共3页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
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