摘要
目的分析螺旋CT分别联合血清糖类抗原125(CA125)、附睾蛋白4(HE4)、甲胎蛋白(AFP)在卵巢癌诊断中的应用价值。方法选取2015年6月至2017年8月济宁医学院附属医院诊治的112例经病理学诊断确诊为卵巢癌的患者进行回顾性分析。其中恶性肿瘤52例,良性肿瘤60例。收集所有患者的螺旋CT检查结果,以及血清CA125、HE4和AFP的检测结果,分析比较螺旋CT与不同标志物分别联合检测在卵巢癌早期诊断中的应用价值。结果与良性肿瘤组患者相比,恶性肿瘤组患者的血清CA125、 HE4和AFT水平均明显更高,差异存在统计学意义(P<0.05)。采用螺旋CT分别联合CA125、HE4和AFP对卵巢癌良恶性的鉴别诊断,对应病理诊断(金标准)结果,螺旋CT、CA125、HE4和AFP联合检测对卵巢癌诊断效果最好(灵敏度=92.3%,特异度=93.3%,准确率=92.9%)。结论螺旋CT联合血清CA125、CA199和AFP检测能够提高卵巢癌诊断的灵敏度、特异度及准确率,具有重要的临床意义。
Objective To analyze the application value of spiral CT combined with serum carbohydrate antigen 125(CA125), humanepididymis protein 4(HE4) and alpha fetoprotein(AFP) in the diagnosis of ovarian cancer. Methods Retrospective analysis of 112 patients with ovarian cancer diagnosed by pathology from June 2015 to August 2017 was performed, including 52 cases of malignant tumors and 60 cases of benign tumors.The results of spiral CT examination of all patients, as well as the results of serum CA125, HE4 and AFP were collected. The application value of spiral CT combined with different markers in the early diagnosis of ovarian cancer was compared.Results Compared with patients with benign tumors, the serum CA125, HE4 and AFT levels were significantly higher in the malignant tumor group, with statistically significant differences(P<0.05). Differential diagnosis of benign and malignant ovarian cancer by spiral CT combined with CA125, HE4 and AFP showed that corresponding to the pathological diagnosis(gold standard) results, the combined detection of the four markers for ovarian cancer diagnosis(sensitivity=92.3%, specificity=93.3%, accuracy=92.9%) was the best. Conclusions Spiral CT combined with serum CA125, CA199 and AFP detection can improve the sensitivity, specificity and accuracy of ovarian cancer diagnosis, which is of important clinical significance.
作者
徐洁
王彦辉
史志涛
朱来敏
姜鑫
XU Jie;WANG Yanhui;SHI Zhitao;ZHU Laimin;JIANG Xin(Department of Imagings Affiliated Hospital of Jining Medical College,Jirdng 272029,Shandong,China)
出处
《中国性科学》
2019年第9期43-45,共3页
Chinese Journal of Human Sexuality
关键词
螺旋CT
糖类抗原125
附睾蛋白4
甲胎蛋白
卵巢癌
Spiral CT
Carbohydrate antigen 125(CA125)
Humanepididymis protein 4(HE4)
Alpha-fetoprotein(AFP)
Ovarian cancer
