摘要
为寻找活性更高的药物,根据前药原理和拼合原理将姜黄素与硝酸酯类一氧化氮(NO)供体设计成姜黄素前药衍生物;以姜黄素为起始原料,将其用二溴烷烃醚化合成得到姜黄素溴代烷基醚中间体,再将其与硝酸银反应成酯得到目标化合物姜黄素硝氧烷基酯衍生物;目标化合物经IR、1H-NMR和MS表征确证为硝酸酯类NO供体型姜黄素衍生物。硝酸酯类姜黄素衍生物的合成方法简便可行,可为进一步生物活性测试提供原料。
To search for more active antitumor drugs,curcumin and nitrate NO donor were designed as curcumin prodrug derivatives according to prodrug principle and conjugation principle.Curcumin is the starting material,the intermediates of curcumin bromide alkyl ether were synthesized by etherification with 2 bromo alkanes.Then it was reacted with silver nitrate to form esters to obtain curcuminnitryl alkyl ester derivatives.The target compound was confirmed to be nitrate NO donor curcumin derivatives by IR,1H-NMR and MS characterization.The synthetic method of curcumin derivatives of nitrate esters is simple and feasible,which can be used as raw materials for further bioassay.
作者
陈维珍
徐济恒
徐苏丽
CHEN Weizhen;XU Jiheng;XU Suli(Department of Medicine,Huangshan Vocational and Technical College,Huangshan 245000,China)
出处
《宿州学院学报》
2019年第9期77-80,共4页
Journal of Suzhou University
基金
安徽省高校科学研究项目(KJ2019H04)
安徽省高校优秀青年骨干人才国内访学研修项目(gxgnfx2018122)
