摘要
目的探讨肿瘤标志物检测对黏液性卵巢肿瘤的诊断价值。方法根据组织病理学方法,将128例黏液性卵巢肿瘤患者分为卵巢黏液性囊腺瘤(MCO)组52例,卵巢交界性黏液性囊腺瘤(BOMC)组36例,卵巢黏液性癌(MOC)组40例,回顾性分析3组患者血清中糖类抗原(CA)125、CA199、癌胚抗原(CEA)、甲胎蛋白(AFP)、人附睾蛋白4(HE4)的水平差异。结果BOMC组CA125、CA199水平明显高于MOC组和MCO组,MOC组HE4水平明显高于MCO组和BOMC组,BOMC组CA199阳性值水平明显高于MCO组和MOC组,差异均有统计学意义(P<0.05)。CA199阳性值对鉴别BOMC、MOC的受试者工作特征曲线下面积为0.57(95%CI:0.35~0.79,P=0.516),当CA199的cut off值为758.65U/mL时,其对应的敏感度为0.417,特异度为0.842。结论血清CA125、CA199、HE4检测对黏液性卵巢肿瘤有一定诊断价值。
Objective To evaluate the value of serum tumor markers in the diagnosis of mucous ovarian tumors.Methods Clinical data of 128 patients with mucous ovarian tumors were collected,including 52 cases of mucinous cystadenoma of ovary(MCO group),36 cases of borderline ovarian mucinous cystadenoma(BOMC group)and 40 cases of mucinous ovarian cancer(MOC group).The serum levels of tumor markers carbohydrate antigen(CA)125,CA199,carcinoembryonic antigen(CEA),alpha fetoprotein(AFP)and human epididymis protein 4(HE4)were measured and compared between three groups.Results Serum CA125 and CA199 level of BOMC group were significantly higher than that in MOC group and MCO group,serum HE4 level of MOC group was significantly higher than that in BOMC group and MCO group,serum CA199 positive value of BOMC group was significantly higher than that in MCO and MOC group(P<0.05).AUC of CA199 differential diagnosis in BOMC and MOC was 0.57(95%CI:0.35-0.79,P=0.516).When the cut-off value of CA199 was 758.65 U/mL,its sensitivity and specificity were 0.417 and 0.842.Conclusion Serum CA125,CA199 and HE4 value have certain diagnostic value for mucinous ovarian tumors.
作者
宋元平
石杨杨
申震
朱靖
卫莹
周颖
吴大保
SONG Yuanping;SHI Yangyang;SHEN Zhen;ZHU Jing;WEI Ying;ZHOU Ying;WU Dabao(Anhui Medical University,Hefei,Anhui 230032,China;Department of Obstetrics and Gynecology,Provincial Hospital Affiliated to Anhui Medical University,Hefei,Anhui 230001,China)
出处
《检验医学与临床》
CAS
2019年第20期2913-2916,共4页
Laboratory Medicine and Clinic
基金
国家自然科学基金项目（81272881）
关键词
卵巢黏液性囊腺瘤
卵巢交界性黏液性囊腺瘤
卵巢黏液性癌
糖类抗原125
糖类抗原199
癌胚抗原
甲胎蛋白
人附睾蛋白4
mucinous cystadenoma of ovary
borderline ovarian mucinous cystadenoma
mucinous ovarian cancer
carbohydrate antigen 125
carbohydrate antigen 199
carcinoembryonic antigen
alpha fetoprotein
human epididymis protein 4
