摘要
目的建立新疆地区8~<11岁儿童甲状腺功能指标[促甲状腺素(TSH)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)]正常参考值范围,为临床诊断标准提供依据。方法整群抽取方法选取新疆14个地州中30个县市8~<11岁学龄儿童1 368例,男691例,女677例,收集血清,采用德国罗氏E411型全自动化学发光免疫分析仪检测甲状腺功能5项指标。结果按照甲状腺功能指标差异无统计学意义合并结果,最终确定各年龄组不同民族参考值范围为:8~<9岁组为T31.86~3.58nmol/L,T4 88.23~157.77nmol/L,FT3 4.72~8.40pmol/L,FT4 12.38~20.06pmol/L,TSH0.94~9.77μIU/mL(维吾尔族),TSH 1.51~9.09μIU/mL(汉族);9~<10岁组为T3 1.92~3.40nmol/L,T485.87~161.25nmol/L,FT3 5.07~7.93pmol/L,FT4 12.52~20.08pmol/L,TSH 1.04~8.13μIU/mL(维吾尔族),TSH 1.40~8.86μIU/mL(汉族);10~<11岁组为T3 1.97~3.69nmol/L,T4 87.73~164.29nmol/L,FT3 5.10~8.16pmol/L,FT4 12.37~20.13pmol/L,TSH 1.26~8.77μIU/mL。结论新疆8~<11岁儿童甲状腺功能指标在不同年龄、不同民族之间有一定差异,需根据实际情况建立适合新疆地区学龄儿童甲状腺功能指标的正常参考值范围,为儿童甲状腺疾病的临床诊断和预防监测提供依据。
Objective To establish the normal reference ranges of thyroid function indicators[thyrotropin(TSH),triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3),free thyroxine(FT4)]in children aged 8-<11 in Xinjiang,and to provide basis for clinical diagnostic criteria.Methods A total of 1 368 school children aged 8-<11 years(691 males and 677 females)from 30 counties in 14 regions of Xinjiang were selected by cluster extraction method.Serum samples were collected and five indicators of thyroid function were detected by Roche E411 automatic chemiluminescence immunoassay.Results According to the combined results if there was statistically significant differences in thyroid function indexes,the reference value range for different age groups and ethnic groups was determined as follows:8-<9 year-old group,T3 1.86-3.58 nmol/L,T4 88.23-157.77 nmol/L,FT3 4.72-8.40 pmol/L,FT4 12.38-20.06 pmol/L,TSH 0.94-9.77μIU/mL(Uygur),TSH 1.51-9.09μIU/mL(Han);9-<10 year-old group,T3 1.92-3.40 nmol/L,T4 85.87-161.25 nmol/L,FT3 5.07-7.93 pmol/L,FT4 12.52-20.08 pmol/L,TSH 1.04-8.13μIU/mL(Uygur),TSH 1.40-8.86μIU/mL(Han);10-<11 year-old group,T3 1.97-3.69 nmol/L,T4 87.73-164.29 nmol/L,FT3 5.10-8.16 pmol/L,FT4 12.37-20.13 pmol/L,TSH 1.26-8.77μIU/mL.Conclusion The thyroid function indexes of children aged 8-<11 in Xinjiang have certain differences among different ages and ethnic groups.It is necessary to establish a proper reference range of thyroid function indexes for school-age children in this region according to the actual situation,so as to provide a basis for clinical diagnosis,prevention and monitoring of thyroid diseases in children.
作者
黄佳
马品江
王琛琛
张玲
HUANG Jia;MA Pinjiang;WANG Chenchen;ZHANG Ling(Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi,Xinjiang 830002,China;Xinjiang Medical University,Urumqi,Xinjiang 830054,China)
出处
《检验医学与临床》
CAS
2019年第20期2936-2938,共3页
Laboratory Medicine and Clinic
基金
新疆维吾尔自治区自然科学基金项目（2018D01C086,2016D01C064）
关键词
学龄儿童
甲状腺功能
参考值
school-age children
thyroid function
reference value
