摘要
目的建立南水北调水源区中心城市十堰市不同孕期孕妇血清甲状腺功能指标参考值。方法以597例健康单胎孕妇作为观察组,595例非妊娠期健康妇女作为对照组。采用化学发光法检测观察组孕早、中、晚期及对照组血清甲状腺激素水平,以中位数和95%可信区间表示生物参考区间(参考值),并绘制不同孕期甲状腺激素变化趋势图。结果观察组孕早、中、晚期血清促甲状腺素、游离三碘甲状腺原氨酸、总三碘甲状腺原氨酸、游离甲状腺素和总甲状腺素水平变化较大,不同孕期组内比较及与对照组比较,差异均有统计学意义(P<0.05),且与美国甲状腺学会指南制定的参考值存在差异。结论该参考值可作为十堰市孕妇筛查和诊治甲状腺疾病的重要参考依据。
Objective To establish the reference value of serum thyroid functions of pregnant women in Shiyan city,the central city of the water source area of The South-to-North Water Transfer Project.Methods A total of 597 healthy single tire pregnant women were taken as observation group and 595 non-pregnant healthy women were selected as control group.The thyroid hormone levels in the early,middle and late pregnancy and the control group were detected by chemiluminescence.The median and 95%confidence interval were used to represent the biological reference interval(reference value)and trend chart of thyroid hormone changes in different stages of pregnancy were plotted.Results Serum total thyroxine,free triiodothyronine,total triiodothyronine,free thyroxine and total thyroxine varied greatly.And the levels of the indicators in different stages of pregnancy had statistical significances with the control group(P<0.05).And there were differences in reference values developed by the American thyroid Association(ATA)guidelines.Conclusion The above reference value can be used as an important reference for screening and diagnosis of thyroid diseases in pregnant women in this area.
作者
陈永梅
范荣梅
龚兴瑞
CHEN Yongmei;FAN Rongmei;GONG Xingrui(School of Biomedical Engineering,Hubei University of Medicine,Shiyan,Hubei 442000,China;Department of Anesthesiology,Taihe Hospital/Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《检验医学与临床》
CAS
2019年第20期2939-2942,共4页
Laboratory Medicine and Clinic
基金
湖北医药学院人才启动金资助计划项目（2016QDJZR27）
关键词
孕期
血清甲状腺功能
参考值
甲状腺激素
变化趋势
gestational stages
serum thyroid function
reference range
thyroid hormone
change trend chart
