摘要
目的:探讨百令胶囊辅助丹参多酚酸盐应用于老年糖尿病肾病Ⅳ期患者,对其血糖水平与肾功能的调节作用。方法:选取2017年1月至2018年1月湖北省黄石市第二医院收治的老年糖尿病肾病Ⅳ期病例130例作为研究对象,按照随机数字表法分为对照组和观察组,每组65例。对照组采取丹参多酚酸盐单纯给药治疗,观察组采取百令胶囊+丹参多酚酸盐治疗。比较治疗前和治疗4周后的2组在血糖水平和肾功能指标方面的变化。结果:1)观察组肾功能β2-MG(2.03±0.84)mmol/L、UPE(120.61±9.25)mg/d、Scr(220.56±12.18)μmol/L、BUN(2.42±0.69)mmol/L、UAER(325.13±12.08)mg/24h显著低于对照组(P<0.05);2)观察组Leptin(7.03±1.09)ng/mL、2hPG(7.61±0.85)mmol/L、HbA1c(7.56±1.23)%、FPG(5.13±1.24)mmol/L显著低于对照组,APN(15.22±2.16)mg/L显著高于对照组(P<0.05);3)观察组总不良反应率7.69%和对照组9.23%差异无统计学意义(P>0.05)。结论:对于老年糖尿病肾病Ⅳ期患者,可采取百令胶囊配合丹参多酚酸盐的中西医结合治疗模式,能有效控制患者血糖水平,改善多项肾功能指标,不良反应较少,具有良好的临床应用价值。
Objective: To investigate the regulation effect of Bailing Capsule combined with salvia miltiorrhiza polyphenolic acid on renal function and blood glucose in elderly patients with stage Ⅳ diabetic nephropathy. Methods: From January 2017 to January 2018,130 cases of elderly patients with stage Ⅳ diabetic nephropathy were selected in the Second Hospital of Huangshi.According to different treatment methods,they were randomly divided into an observation group and a control group.There were 65 cases in each group.The control group was treated with salvia miltiorrhiza polyphenolic acid alone and the experimental group was treated with Bailing Capsule combined with salvia miltiorrhiza polyphenolic acid.The changes of blood glucose and renal function were compared before and after the treatment for 4 weeks. Results: 1)In the observation group,the renal function β2-MG(2.03±0.84)mmol/L,UPE(120.61±9.25)mg/d,Scr(220.56±12.18)μmol/L,BUN(2.42±0.69)mmol/L,UAER(325.13±12.08)mg/24 h were significantly lower than that of the control group( P <0.05);2)In the observation group,Leptin(7.03±1.09)ng/mL,2 hPG(7.61±0.85)mmol/L,HbA1c(7.56±1.23)%,FPG(5.13±1.24)mmol/L were significantly lower than that of the control group and APN(15.22±2.16)mg/L was significantly higher than that of the control group( P <0.05);3)There was no significant difference in the total adverse reaction rate between the observation group(7.69%)and the control group(9.23%)( P >0.05). Conclusion: For the elderly patients with stage Ⅳ diabetic nephropathy,combined therapy of traditional Chinese medicine and western medicine of Bailing Capsule combined with salvia miltiorrhiza polyphenolic acid can effectively control the blood glucose level of the patients,improve renal function indexes,and there are less toxic and side effects which has good clinical application value.
作者
孙胜奎
范银燕
左丽娜
廖建红
Sun Shengkui;Fan Yinyan;Zuo Lina;Liao Jianhong(The Second Hospital of Huangshi,Huangshi 435000,China)
出处
《世界中医药》
CAS
2019年第9期2400-2403,共4页
World Chinese Medicine
基金
湖北省卫计委2015-2016年度科研立项项目(2015-SD45)
关键词
百令胶囊
丹参多酚酸盐
糖尿病肾病Ⅳ期
肾功能
血糖情况
Bailing capsule
Salvia miltiorrhiza polyphenolic acid
Diabetic nephropathy stage Ⅳ
Renal function
Blood glucose
