摘要
神经病理性疼痛是一种常见且顽固的慢性疼痛。越来越多的证据表明脊髓中的小胶质细胞和星形胶质细胞通过释放多种细胞因子和趋化因子,在神经病理性疼痛的产生和维持中发挥着不可或缺的作用。趋化因子CX3CL1及其受体CX3C趋化因子受体1(CX3CR1)作为一种在神经元与胶质细胞相互调控的介质参与神经病理性疼痛的调节。本文主要就CX3CL1/CX3CR1在神经病理性疼痛发病过程中作用的研究进展进行综述。
Neuropathic pain is an intractable chronic pain syndrome. Accumulating evidences suggest that microglia and astrocytes in the spinal cord play an indispensable role in the generation and maintenance of neuropathic pain by releasing a variety of cytokines and chemokines. Chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 serves as one of mediators for neuron-glia communication subsequently modulating neuropathic pain. This article reviews the research progresses of the modulation role of CX3CL1/CX3CR1 in the pathogenesis of neuropathic pain.
作者
冯舒
张析哲
Feng Shu;Zhang Xizhe(Graduate School of Inner Mongolia Medical University,Hohhot City,Inner Mongolia Autonomous Region 010100,China;Department of Anesthesiology of Chifeng Municipal Hospital,Chifeng City,Inner Mongolia Autonomous Region 024000,China)
出处
《实用疼痛学杂志》
2019年第4期298-302,共5页
Pain Clinic Journal
基金
内蒙古医科大学科技百万工程联合项目(YKD2017KJBW(LH)073).
