摘要
目的观察布地奈德联合沙丁胺醇雾化吸入治疗小儿呼吸阻塞的临床疗效.方法 2016年2月~2018年2月我院收治的68例呼吸阻塞患儿作为观察对象,按照随机数字法则分成两组,每组34例.给予对照组沙丁胺醇雾化吸入治疗,给予观察组布地奈德联合沙丁胺醇雾化吸入治疗,并对两组临床治疗效果、临床症状改善时间、用药不良反应发生率及治疗前后患儿肺功能改善情况进行观察.结果治疗后观察组临床治疗总有效率为97.1%,显著优于对照组的82.4%.差异有统计学意义(P<0.05);治疗后观察组患儿的哮鸣音改善时间为(4.4±0.9)d、喘息改善时间为(2.8±0.3)d、咳嗽改善时间为(3.2±0.6)d以及呼吸困难改善时间(3.4±0.7)d,均明显短于对照组,差异有统计学意义(P<0.05);治疗后观察组患儿用药不良反应发生率为23.5%,对照组患儿用药不良反应发生率为20.6%,差异无统计学意义(P>0.05);治疗前两组患儿肺功能指标比较差异无统计学意义(P>0.05);治疗后观察组患儿肺功能FEV1为(1748.4±97.9)mL,FVC为(86.3±8.5)%,PEF为(12.5±1.8)%,显著优于对照组,差异有统计学意义(P<0.05).结论针对小儿呼吸阻塞给予布地奈德联合沙丁胺醇雾化吸入治疗可有效提高临床治疗效果,肺功能得到有效改善.
Objective To observe the clinical efficacy of budesonide combined with salbutamol aerosol inhalation in the treatment of respiratory obstruction in children. Methods 68 children with respiratory obstruction admitted to our hospital from February 2016 to February 2018 were observed and divided into two groups according to the random number rule, with 34 cases in each group. The control group was given salbutamol aerosol inhalation, and the observation group was treated with budesonide combined with salbutamol aerosol inhalation. The clinical treatment effect, the improvement of clinical symptoms, the incidence of adverse drug reactions and the improvement of lung function in children before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 97.1%, which was significantly better than that of the control group (82.4%). The difference was statistically significant (P<0.05). After treatment, the improvement time of wheezing in the observation group was (4.4±0.9) d, the improvement time of gasping was (2.8±0.3) d, the improvement time of cough was (3.2±0.6) d and the improvement time of dyspnea was (3.4±0.7) d, which were significantly shorter than those in the control group, and the differences were statistically significant(P<0.05). After treatment, the incidence of adverse drug reactions in the observation group was 23.5%, the incidence of adverse drug reactions in the control group was 20.6%, and the difference was not statistically significant(P>0.05). There was no significant difference in lung function between the two groups before treatment(P>0.05). The functional FEV1 was (1748.4±97.9) mL, FVC was (86.3±8.5)%, and PEF was (12.5±1.8)% in the observation group after treatment, which were significantly better than those in the control group. The differences were statistically significant(P<0.05). Conclusion Aerosol inhalation of budesonide combined with salbutamol in children with respiratory obstruction can effectively improve the clinical treatment effect and improve lung function.
作者
徐敏智
樊慧苏
吴俊
XU Minzhi;FAN Huisu;WU Jun(Department of Pediatrics,the People's Hospital of Lishui City in Zhejiang Province,Lishui 323000,China;Department of Pediatrics,Lishui Hospital of Traditional Chinese Medicine in Zhejiang Province,Lishui 323000,China)
出处
《中国现代医生》
2019年第26期62-65,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2018KY927)
关键词
布地奈德
沙丁胺醇
雾化吸入
小儿呼吸阻塞
Budesonide
Salbutamol
Aerosol inhalation
Pediatric respiratory obstruction
