摘要
目的探讨肿瘤坏死因子受体超家族1B(TNFRSF1B)基因多态性与丙型肝炎病毒(HCV)感染结局的相关性。方法纳入1 645例无HCV感染者,545例HCV清除者,783例HCV慢性化者,采用TaqMan探针法对rs1061622(T > G)和rs1061624(G > A)两个单核苷酸多态性位点(SNP)进行基因分型,并构建单倍型,评估其与HCV感染结局的相关性。结果经logistic回归分析均两个SNPs与HCV感染的易感性和慢性化无相关性(P值均> 0.05)。单倍型分析显示,携带TA单倍型可增加HCV感染的易感性[调整后比值比(OR)= 1.15,95%可信区间(CI):1.01~1.30,P = 0.038)],携带TA和GG单倍型均有利于HCV感染慢性化(调整后OR = 1.28,95% CI:1.08~1.53,P = 0.006;OR = 1.31, 95% CI:1.03~1.66,P = 0.026)。结论TNFRSF1B基因rs1061622和rs1061624的共同效应可增加HCV感染和慢性化的风险。
Objective To investigate the tumor necrosis factor receptor superfamily 1B gene (TNFRSF1B) polymorphism in relation to the outcomes of hepatitis C virus (HCV) infection. Methods One thousand six hundred and forty-five cases without HCV infection, 545 cases with HCV clearance, and 783 cases with chronic HCV infection were enrolled. TaqMan probe method was used to investigate genotype rs1061622 (T > G) and rs1061624 (G > A). Two single nucleotide polymorphisms (SNPs) sites were genotyped and haplotypes were constructed to evaluate their relation with the outcome of HCV infection. Results Logistic regression analysis showed that there was no relation to the two SNPs with HCV infection susceptibility and chronicity (P > 0.05). Haplotype analysis showed that carrier TA had an increased susceptibility to HCV infection [adjusted odds ratio (OR)= 1.15, 95% confidence interval (CI): 1.01 to 1.30, P = 0.038)]. Carrier TA and GG haplotypes were conducive to chronic HCV infection (adjusted OR = 1.28, 95% CI: 1.08 to 1.53, P = 0.006;OR = 1.31, 95% CI: 1.03 to 1.66, P = 0.026). Conclusion The combinational effects of rs1061622 and rs1061624 in TNFRSF1B gene may increase the risk of HCV chronicity and infection.
作者
朱萍
岳明
陈琼
姚敏
巫晶晶
邵建国
薛红
张云
黄鹏
汪春晖
Zhu Ping;Yue Ming;Chen Qiong;Yao Min;Wu Jingjing;Shao Jianguo;Xue Hong;Zhang Yun;Huang Peng;Wang Chunhui(Medical Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Eastern Theater Command Centers for Disease Control and Prevention, Nanjing 210002, China;Department of Immunology, Medical School of Nantong University, Nantong 226001, China;Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China;Department of Gastroenterology, the Nantong Third Affiliated Hospital of Nantong University, Nantong 226001, China;Fourth Ward, the Nantong Third Affiliated Hospital of Nantong University, Nantong 226001, China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2019年第10期793-798,共6页
Chinese Journal of Hepatology
关键词
肝炎病毒
丙型
肿瘤坏死因子受体超家族1B
基因多态性
慢性化
Hepatitis C virus
Tumor necrosis factor receptor superfamily member 1B
Gene polymorphism
Chronicity
